CASR Antibody
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中文名稱：CASR兔多克隆抗體
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貨號：CSB-PA443839
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規格：￥2015
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圖片：
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Western blot analysis of Calcium Sensing Receptor expression in LOVO whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CASR Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：A synthesized peptide derived from Human Calcium Sensing Receptor
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
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基因功能參考文獻：
- Performed cytogenetic analysis in 23 patients with Sagliker syndrome; found base alterations and deletions in exons 2 and 3 of the calcium sensing receptor (CaSR) gene. PMID: 28263480
- Based on these findings, ischemia/reperfusion-induced MCPIP1 expression regulates the migration and apoptosis of human vascular endothelial cells via HMGB1 and CaSR, respectively. PMID: 29379093
- expressions of p27(Kip1) and CaSR were decreased in primary hyperparathyroidism patients PMID: 29589297
- Study presents the novel concept that CaSR activation stimulates autophagy in preadipocytes, which in turn mediates the elevation of TNFalpha production. PMID: 30251678
- The identification of the activation of CaSR-mediated protective pathway in renal cells sheds light on a possible cellular protective mechanism against Cd-induced kidney injury. PMID: 29348484
- These findings suggest an inhibitory role for CaSR in endometrial cancer. Therefore, reduced CaSR expression may be a suitable explanation and valuable predictor for endometrial cancer progression. PMID: 29348629
- We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype.Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population. PMID: 30407299
- The variant allele of CASR rs1801725 solely and together with the variant allele of rs7652589 increases risk of more advanced secondary hyperparathyroidism. PMID: 29763933
- findings confirm the expression of CaSR in human BM-derived MSCs and unravel a prominent role for the interplay between CaSR and PTH1R in regulating MSC fate and the choice of pathway for bone formation. PMID: 29915064
- Genetic polymorphism of calcium-sensing receptor is associated with breast cancer. PMID: 29387985
- The low prevalence of CaSR autoantibodies indicate a very low level of subclinical parathyroid autoimmunity in APS types 2, 3 and 4. PMID: 28941288
- CaSR Arg990Gly polymorphism is associated with the risk of nephrolithiasis development in a Chinese population. PMID: 28609763
- TRPC1 is a primary candidate in forming SOCC that stimulates CaSRinduced SOCE and NO production in HUVECs PMID: 28791397
- The c.2195A>G, p.(Asn732Ser) mutation in exon 7 of the CaSR gene leads to hypocalcaemia, and has not been reported before in the medical literature. 2) Possibly, this mutation is linked to premature baldness. PMID: 28741586
- CASR SNPs may partly explain differences in the clinical manifestations of CKD-MBD between european and African ancestry populations, and in the biochemical response to cinacalcet in many patients. PMID: 28630081
- Decreased sensitivity of the CaSR to calcium due to inactivating polymorphisms at rs1801725, may predispose up to 20% of breast cancer cases to high circulating calcium-associated larger and/or aggressive breast tumors. PMID: 28764683
- This study shows that the A allele of rs7652589 is a risk allele for nephrolithiasis-related end stage renal disease. The AA genotype is associated with more severe secondary hyperparathyroidism (higher calcium and parathormone concentrations). PMID: 27739473
- Polymorphism of the Calcium-Sensing Receptor Gene is associated with Breast Cancer Risk.[review] PMID: 29504802
- Data show that Cao2+ via CaR- mediated signaling induces filamin A cleavage and promotes the migration in AR-deficient and highly metastatic prostate cancer cells. PMID: 27206800
- GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR. PMID: 27760455
- this study, demonstrates for the first time that calcium exerts an oncogenic action in the stomach through activation of CaSR and TRPV4 channels. Both CaSR and TRPV4 were involved in Ca2+-induced proliferation, migration, and invasion of gastric cancer cells through a Ca2+/AKT/beta-catenin relay, which occurred only in gastric cancer cells or normal cells overexpressing CaSR. PMID: 28951460
- mutagenesis with a novel analytical approach and molecular modeling to develop an "enriched" picture of structure-function requirements for interaction between Ca(2+)o and allosteric modulators within the CaSR's 7 transmembrane (7TM) domain, is reported. PMID: 27002221
- FLNA is downregulated in parathyroid tumors and parallels the CASR expression levels. Loss of FLNA reduces CASR mRNA and protein expression levels and the CASR-induced ERK phosphorylation. FLNA is involved in receptor expression, membrane localization and ERK signaling activation of both 990R and 990G CASR variants. PMID: 27872158
- A father and daughter with asymptomatic chronic hypocalcemia with low parathyroid hormone and inappropriate urinary calcium excretion had a missense mutation in exon 7: c.2621G>T (p.Cys874Phe). PMID: 27663953
- These results support the emerging potential of CaSR as a therapeutic target in metastatic breast cancer whose pharmacological modulation would reduce IL-6. PMID: 27477783
- These structures reveal multiple binding sites for Ca(2+) and PO4(3-) ions. Both ions are crucial for structural integrity of the receptor. While Ca(2+) ions stabilize the active state, PO4(3-) ions reinforce the inactive conformation. PMID: 27434672
- The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. PMID: 28419469
- Glucose acts as a positive allosteric modulator of CaSR. PMID: 27613866
- These studies indicate that the CaSR activation impairs glucose tolerance by a combination of alpha- and beta-cell defects and also influences pancreatic islet mass. PMID: 28575322
- Minor alleles rs7652589 and rs1501899 are associated with reduced CaSR expression in neuroblastic tumors and neuroblastoma cell lines in which the CASR gene promoter P2 is not hypermethylated. PMID: 27862333
- Calcium exerted its effects on cartilaginous endplates matrix protein synthesis through activation of the extracellular calcium-sensing receptor. PMID: 27452962
- Polymorphic variations in VDR and CASR may be associated with survival after a diagnosis of colorectal neoplasms. PMID: 28765616
- CaSR and AP2S1 sequencing is worthwhile in patients with familial hyperparathyroidism and phenotype suggesting familial hypocalciuric hypercalcemia as it can diagnose up to 50% of cases. PMID: 28176280
- reduced expression of the CaSR is correlated with activation of the renin-angiotensin system, which induces increased vascular remodeling and vascular smooth muscle cell proliferation, and thereby associated with essential hypertension in the SHR rat model and in the Han Chinese population PMID: 27391973
- CaSR exerts a suppressive function in pancreatic tumorigenesis through a novel NCX1/Ca(2+)/beta-catenin signaling pathway. PMID: 27108064
- In whites, CaSR gene SNP rs1801725 was associated with serum calcium but not with risk of diabetes. PMID: 27510541
- Tumor CaSR expression is associated with an increased risk of lethal prostate cancer, particularly in tumors with low VDR expression. PMID: 27115058
- Functional interaction of upregulated CaSR and upregulated TRPC6 in pulmonary artery smooth muscle cells from idiopathic pulmonary arterial hypertension patients may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling. PMID: 26968768
- This is a prospective observational study that measures the expression of vitamin D (VD) metabolising and signalling molecules and Ca(2+) sensing receptor (CaSR) in human Fallopian tube (FT) during the menstrual cycle and ectopic pregnancy (EP). PMID: 27770255
- CaSR expression was shown in HepG2 cells and human liver samples; CaSR may contribute to obesity-associated hepatic metabolic consequences PMID: 27565442
- Polymorphisms of CASR gene increase the risk of primary hyperparathyroidism. PMID: 26710757
- Calcium oxalate-induced renal injury is related to CaSR-mediated oxidative stress and increased mitogen-activated protein kinase signaling, which subsequently leads to CaOx crystal adhesion. PMID: 27965733
- The detection of CaSR gene mutations is suitable to differentiate states of hypercalcemia and may help to avoid invasive procedures such as parathyroidectomies. PMID: 27926951
- a novel loss-of-function mutation, G571W, in the CaSR gene in a Korean family with familial hypocalciuric hypercalcemia. PMID: 26386835
- There is a significant correlation between in vitro functional impairment of the CaSR at physiologic calcium concentrations and the severity of alterations in calcium homeostasis in patients. PMID: 27666534
- Calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer. PMID: 25124570
- physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR. PMID: 26911344
- CaSR and PTH1R signaling responses in cartilage and bone. [review] PMID: 26688334
- The calcium-sensing receptor may be involved in the modulation of inflammatory processes. [review] PMID: 26303192
- A986S polymorphism of CaSR is an independent predictor of PTH level in normocalcemic hyperparathyroidism patients, but not in asymptomatic hyperparathyroidism. PMID: 26332755
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相關疾病：Hypocalciuric hypercalcemia, familial 1 (HHC1); Hyperparathyroidism, neonatal severe (NSHPT); Hypocalcemia, autosomal dominant 1 (HYPOC1); Epilepsy, idiopathic generalized 8 (EIG8)
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 3 family
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組織特異性：Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
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數據庫鏈接：
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