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中文名稱：小鼠Ⅰ型前膠原N端前肽(PⅠNP)酶聯免疫試劑盒
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貨號：CSB-E12775m
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規格：96T/48T
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價格：￥3600/￥2500
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促銷：
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其他：
產品詳情
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產品描述：小鼠Ⅰ型前膠原N端前肽(PⅠNP)酶聯免疫試劑盒（CSB-E12775m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的PⅠNP含量。PⅠNP是一種重要靶點。其與骨代謝密切相關，可反映成骨細胞活性。研究機制上，通過檢測血液中其含量變化，能評估骨形成狀態，在骨質疏松等骨骼疾病的診斷、病情監測及治療效果評估等研究中發揮著關鍵作用。試劑盒檢測范圍為4.7 pg/mL-300 pg/mL，PⅠNP可作為骨形成和纖維化進程的關鍵生物標志物，在骨代謝研究、纖維化疾病模型評估及藥物干預效果分析中具有重要科研價值。適用于研究骨發育異常、骨質疏松模型、肝/肺纖維化機制探索等科研領域，為相關疾病模型的生物標志物分析提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：procollagen 1 N-terminal peptide,P1NP,_x000D_ procollagen I N-terminal peptide,PINP
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縮寫：PⅠNP
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：4.7 pg/mL-300 pg/mL
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靈敏度：1.17 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Others
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of mouse PINP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:100 Average % 92 Range % 87-98 1:200 Average % 95 Range % 91-98 1:400 Average % 91 Range % 85-96 1:800 Average % 94 Range % 88-102 -
回收率：
The recovery of mouse PINP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 96 89-99 EDTA plasma (n=4) 89 82-94 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 300 2.413 2.313 2.363 2.261 150 1.598 1.498 1.548 1.446 75 0.940 0.890 0.915 0.813 37.5 0.489 0.479 0.484 0.382 18.75 0.316 0.306 0.311 0.209 9.4 0.207 0.205 0.206 0.104 4.7 0.145 0.142 0.144 0.042 0 0.103 0.101 0.102 -
數據處理：
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貨期：3-5 working days
引用文獻
- RKIP regulates bone marrow macrophage differentiation to mediate osteoclastogenesis and H-type vessel formation Z Zheng, S Tao, J Jin, Y Li, L Dai, Z Huang,Nature Communications,2025
- Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C Y Xie, M Pan, Z Zhang, L Zhang, H Liu,Advanced Science,2025
- Stephanine Protects Against Osteoporosis by Suppressing Osteoclastogenesis via Inhibition of the RANKL—RANK Interaction T Liu, J Li, M Duan, Y Wang, Z Jiang,Journal of Cellular and Molecular Medicine,2024
- Altered post-fracture systemic bone loss in a mouse model of osteocyte dysfunction B Osipov, AJ Emami, HC Cunningham, S Orr,JBMR plus,2024
- FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism C Cheng, M Deng, C Cheng, H Wu, Y Wang,Journal of Orthopaedic Translation,2024
- Hybrid complex of tyrosinase and carbon-based materials for tissue engineering applications ???,????? ???,2024
- Single-Walled Carbon Nanotube-Guided Topical Skin Delivery of Tyrosinase to Prevent Photoinduced Damage J Ko,ACS nano,2023
- FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress_x001e_mediated ferroptosis Q Dong,Journal of orthopaedic surgery and research,2024
- Activation of TAZ by XMU-MP-1 inhibits osteoclastogenesis and attenuates ovariectomy-induced cancellous bone loss X Li,Biochemical and biophysical research communications,2023
- Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts KY Wong,Phytotherapy research,2023
- Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss M Ghoneum,Signal transduction and targeted therapy,2024
- Cervical vertebrae for early bone loss evaluation in osteoporosis mouse models B Teng,Quantitative imaging in medicine and surgery,2023
- Identification and characterization of NFATc1+ skeletal stem cells in bone regeneration F Yu,Cell reports,2022
- Peptide modified geniposidic acid targets bone and effectively promotes osteogenesis M Liu,Journal of Orthopaedic Translation,2022
- Asiatic acid improves high-fat-diet-induced osteoporosis in mice via regulating SIRT1/FOXO1 signaling and inhibiting oxidative stress X Chen,Histology and histopathology,2022
- SIS3 suppresses osteoclastogenesis and ameliorates bone loss in ovariectomized mice by modulating Nox4-dependent reactive oxygen species Wenzheng Pan,Biochemical pharmacology,2021
- Conditional Knockout of PDK1 in Osteoclasts Suppressed Osteoclastogenesis and Ameliorated Prostate Cancer-Induced Osteolysis Y Zhang,Researchsquare,2021
- Mutations in Profilin 1 cause early-onset Paget's disease of bone with giant cell tumors Z Wei,Journal of Bone and Mineral Research,2021
- Conditional knockout of the PDK‐1 gene in osteoblasts affects osteoblast differentiation and bone formation Y Bai,Journal of Cellular Physiology,2021
- Acanthopanax senticosus aqueous extract ameliorates ovariectomy-induced bone loss in middle-aged mice by inhibiting the receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis H Xu,Food & Function,2020
- Hydrogen sulfide protects against particle┸\induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening Liu L,FASEB,2020
- The emerging role of IMD 0354 on bone homeostasis by suppressing osteoclastogenesis and bone resorption, but without affecting bone formation Chen W, et al,Cell Death and Disease,2019
- A novel transgenic murine model with persistently brittle bones simulating osteogenesis imperfecta type I Yi Liu, et al,Bone,2019
- Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency Monajemi M, et al,Journal of Leukocyte Biology,2019
- A novel anti-osteoporotic agent that protects against postmenopausal bone loss by regulating bone formation and bone resorption Yu-te Yang .et al,Life Sciences,2018
- A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-and IκBα-Mediated p65 Nuclear Translocation Xie, Zi\'ang.et al,Journal of Bone and Mineral Research ,2017
- Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice Khorasani MS.et al,Arthritis Res Ther.,2015
- Altered bone development in a mouse model of peripheral sensory nerve inactivation. Heffner MA et al,J Musculoskelet Neuronal Interact,2014
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