Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Inhibin deficient mice are viable but are acutely sensitive to development of gonadal sex-cord stromal tumors.

1. These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis. PMID: 28205525
2. This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells. PMID: 27465829
3. The study is the first to identify an intratesticular role for inhibin/inhibin-alpha subunit, demonstrating that a threshold level of this protein is required for normal testis development and to sustain adult somatic testicular cell function. PMID: 25781564
4. inhibin is a broad regulatory marker in anterior pituitary cells PMID: 24098340
5. A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model. PMID: 23446452
6. Data indicate that the inhibin-alpha promoter is activated synergistically by Wt1 and Sf1. PMID: 23326390
7. Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling. PMID: 22267736
8. relationship between inhibin and Sertoli cell activity PMID: 21998670
9. These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis. PMID: 21408162
10. There are widespread alterations in the transcriptome of gonadotropin-treated Inha-/- granulosa cells, with significant changes in genes involved in extracellular matrix and cell-cell communication. PMID: 20739397
11. Results demonstrate that RB is not essential for Sertoli cell tumorigenesis in Inha KO mice but that loss of Inha accelerates the infertility phenotype of Rb cKO mice. PMID: 20676395
12. SMAD 2 is not required for mediating tumorigenic signals of activin in ovarian tumor development caused by loss of inhibin. PMID: 20565978
13. beta-catenin synergizes with steroidogenic factor-1 to activate the alpha-inhibin promoter through formation of a transcriptional complex PMID: 12732619
14. inhibin-alpha gene expression is developmentally regulated in the mouse testis PMID: 15055530
15. Transregulation of LH receptor (LHR) and transcription factor GATA-4, coexpressed during the adrenocortical tumorigenesis of prepubertally gonadectomized transgenic (TG) mice expressing the inhibin alpha-subunit PMID: 15256532
16. LRH-1 and SF-1 act similarly to increase promoter activity of inhibin alpha. PMID: 16423880
17. Activin A has opposite effects on glucagon and arx gene expression in alpha-cells compared with beta-cells, a finding that may have relevance during pancreatic endocrine lineage specification and physiological function of the adult islets PMID: 16988001
18. Gonadal InhA may be a component of the normal endocrine repertoire that regulates bone quality in both the axial and appendicular skeleton. PMID: 17194739
19. concurrent loss of Rb and inhibins in the ovary will exacerbate tumor formation PMID: 17510234
20. LH is not required for tumor formation in the absence of inhibins but promotes tumor progression, likely through alterations in serum hormone levels and cell cycle regulators. PMID: 18657590
21. The expression of inhibin isotypes increases progressively in the testis of mice with increasing postnatal age, suggesting that inhibin is associated with a negative feedback signal for FSH in testicular maturation. PMID: 19043308
22. analysis of inhibin alpha null mice uncovered a delay in early thymocyte development and decreased thymocyte numbers in vitro, supporting the role of activins and inhibins during T cell development in vivo. PMID: 19338778
23. These results demonstrated that endocrine effects of inhibin as a negative feedback controller of follicle stimulating hormone production in gonadotropes are dependent on betaglycan expression. PMID: 19524135
24. Absence of inhibin alpha resulted in advanced follicular maturation. Regulation of the inhibin/activin system is essential for early folliculogenesis in the prepubertal mouse ovary. PMID: 19666016

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Secreted.

TGF-beta family

KEGG: mmu:16322

STRING: 10090.ENSMUSP00000040310

UniGene: Mm.1100