The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

1. down-regulated in cord blood by prenatal smoking PMID: 28130959
2. the interaction between the HLA-DRB1*1501 allele and MBP gene may be considered as a predisposing factor in the development and pathogenesis of multiple sclerosis in the case of gene-gene interaction PMID: 28919586
3. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients. PMID: 28537443
4. Studied potential use of myelin basic protein (MBP) as a biomarker in CSF of brain cancer patients. Results suggest that the presence of MBP in CSF may be considered as an indicator of the brain tumor development. PMID: 29028399
5. t-PA binds to Lys91 in the MBP NH2-terminal region and PLG binds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of PLG by t-PA. PMID: 28648598
6. Specific sites of post-translational modifications in multiple sclerosis patients are localized in two zones of MBP suggests that these regions may be involved in antigen recognition by the body's immune surveillance machinery PMID: 27519525
7. Results provide novel insights into the role of genetic variation within the MBP gene predicting multiple sclerosis clinical course, both directly and by interaction with known environmental MS risk factors PMID: 28413712
8. Pathway analysis demonstrated that the majority of the differentially expressed genes (23.3%) were involved in cytokinecytokine receptor interaction. Subsequent to GolliMBP knockdown, the mechanisms that changed the biological characteristics of Jurkat cells were complex, involving numerous types of functional proteins, and metabolic and signaling pathway PMID: 27748888
9. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro. PMID: 27599511
10. This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls. PMID: 26476704
11. myelin basic protein has a role in activating CD4+ and CD8+ T lymphocytes in multiple sclerosis PMID: 26526848
12. B cells from relapsing-remitting multiple sclerosis patients produce TNFa and IL6, and present MBP85-99 peptide PMID: 26756931
13. IL-17- and IL-22-secreting myelin specific CD4(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis. PMID: 26781085
14. Studies indicate that all myelin basic protein (MBP) isoforms are intrinsically disordered proteins (IDPs) that interact via molecular recognition fragments (MoRFs), which thereby undergo local disorder-to-order transitions. PMID: 26518750
15. Reduced myelin basic protein-induced CD4+ T-cell autoreactivity in interferon-beta-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10 PMID: 25738751
16. Negatively charged actin and calmodulin (CaM), as well as basic histone H1.3, inhibit MBP hydrolysis by competing with the proteasome and MBP, respectively, for binding their counterpart. PMID: 25276831
17. data reveal the first case of a pathophysiologically important autoantigen as a ubiquitin-independent substrate of the 26S proteasome. PMID: 24739384
18. Single nucleotide polymorphisms on genetic loci SOD2, MBP and C8orf42were not found significantly associated with advanced age-related macular degeneration in a Chinese cohort PMID: 24667176
19. In autistic children with allergic manifestations there were increased serum levels of MBP (and MAG) compared to those without allergies. PMID: 23726766
20. Association between MBP 5'-side TGGA n gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning. PMID: 23315809
21. Multiple sites of the cleavage of 21- and 25-mer encephalytogenic oligopeptides corresponding to human myelin basic protein (MBP) by specific anti-MBP antibodies from patients with systemic lupus erythematosus. PMID: 23520443
22. Residues K54, R55, G56, and K59 mediate binding of MBP to amyloid beta-protein and inhibition of fibril assembly. PMID: 23510371
23. Fractional anisotropy in the centrum semiovale or pyramidal tract offers a quantitative indicator of the extent of demyelination in damaged cerebral white matter during the subacute phase in carbon monoxide-poisoned patients. PMID: 22258479
24. Mean CSF MBP increases markedly after severe pediatric traumatic brain injury, but is not affected by therapeutic hypothermia. PMID: 22890910
25. Effect of phosphorylation of phosphatidylinositol on myelin basic protein-mediated binding of actin filaments to lipid bilayers in vitro PMID: 22538354
26. Immunization with an MBP, the amino acid residues 83-99 of which are specific for a T-cell receptor (TCR) mouse transgene, induces experimental autoimmune allergic encephalitis in humanized transgenic mice. PMID: 22888134
27. Data show that the acidification followed by neutralisation (AFBN) pre-treatment protocol for cerebrospinal fluid (CSF) significantly enhances the measurement of glutamine synthetase (GS) and myelin basic protein (MBP) in CSF. PMID: 22542401
28. Elevated levels of cerebrospinal fluid MBP seem to reflect a subcortical profile among patients with vascular dementia compared to those with mixed dementia. PMID: 21860087
29. Loss of MBP is associated with aging and hearing loss. PMID: 22496821
30. Type I spiral ganglion nerve somata were surrounded by "satellite glial cells" that lacked expression of MBP indicating that these cells are non-myelinating. Myelination pattern in human spiral ganglion is different from that in other species'. PMID: 21601398
31. Molecular Dynamics simulations of the MuBetaRho 83-99 (Phe91) and MuBetaRho 83-99 (Tyr91) peptide analogues in complex with HLA-DR2 (DRA, DRB1*1501) and T-cell receptors were performed. PMID: 21898163
32. Golli-MBP has a clear effect on oligodendrocyte precursor cell development via modulating multiple divalent calcium ion regulatory events through voltage-operated- and store-operated calcium channels. PMID: 19570024
33. a genetic study in rheumatoid arthritis implicating MBP as a potential autoantigen and its involvement in pathogenesis of the disease PMID: 21673997
34. The GroEL/GroES chamber thus appears to function passively toward Double mutant MBP refolding PMID: 21609718
35. Suggest that golli-MBP is a possible susceptibility gene for schizophrenia in the Jewish Ashkenazi population. PMID: 19154657
36. Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein PMID: 21203542
37. our findings suggest a key role for classical MBP proteins in regulating voltage-gated Ca(2+) channels at the plasma membrane of oligodendroglial cells PMID: 21312222
38. Data show that MBP purified from either brain or a bacterial recombinant expression system comparably bound to Abeta and inhibited Abeta fibril assembly indicating that post-translational modifications are not required for this activity. PMID: 20807757
39. Three single nucleotide polymorphisms (STAT6 rs703817, C1qG rs17433222, and MBP rs3794845) were found to be significantly associated with childhood leukemia risk in Koreans. PMID: 20438785
40. Data show that Golli interacts with the C-terminal domain of STIM1 in both in vitro and in vivo binding assays and this interaction may be modulated by the intracellular Ca(2+) concentration. PMID: 20629634
41. solution structural motif of MBP83-99 (immunodominant epitope) performed using 2D 1H-NMR spectroscopy in dimethyl sulfoxide; residues implicated in T-cell receptor recognition in multiple sclerosis are solvent exposed PMID: 19468823
42. The 21.5 kDa MBP promotes the proliferation of HepG-2 cells and blocks apoptosis. PMID: 19950581
43. Association of MBP tetranucleotide repeat and multiple sclerosis is restricted to a geographically defined subpopulation in Finland. PMID: 12618862
44. Findings of secreted MBP epitopes in all tested sera from healthy donors and from multiple sclerosis patients as well as in sera from normal human cord blood provide insights into the establishment of central and peripheral tolerance to MBP products. PMID: 12965257
45. Decreased expression of a number of myelin-related genes, including myelin basic protein (MBP), proteolipid protein (PLP), and myelin-associated oligodendrocyte basic protein (MOBP) was noted in nucleus accumbens of cocaine abusers PMID: 15009677
46. discovered epitope-specific antibody-mediated degradation of MBP suggests a mechanistic explanation of the slow development of neurodegeneration associated with multiple sclerosis PMID: 16387849
47. Results suggest that human trypsin 4 may be one of the candidate proteases involved in the pathomechanism of multiple sclerosis via cleavage of myelin basic protein. PMID: 16412431
48. Golli-MBP deletion or duplication is rarely involved in inherited defects of myelin formation. PMID: 16441258
49. Immunodomonant MBP 84-106 actively associates with Hsp70 from multiple sclerosis white matter. The complex is higly immunogenic with adjuvant-like effects stimulating MBP peptide-specific T cell lines to respond to sub-optimal concentrations of peptide. PMID: 16842822
50. myelin basic protein charge isomer, component-8, was more susceptible to stromelysin-1 cleavage than myelin basic protein component-1; increased susceptibility of component-8 to proteolytic digestion may play a role in pathogenesis of multiple sclerosis PMID: 16871440

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The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).

Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.; [Isoform 3]: Nucleus. Note=Targeted to nucleus in oligodendrocytes.

Myelin basic protein family

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

HGNC: 6925

OMIM: 159430

KEGG: hsa:4155

UniGene: Hs.551713