Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.

1. The human apolipoprotein MIC26 is a bona fide subunit of the MICOS complex. PMID: 25764979
2. It is likely that apoO participates in fatty acid metabolism and the inflammatory response in HepG2 cells. PMID: 24341743
3. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility. PMID: 24743151
4. relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects and patients with established acute coronary syndrome PMID: 22693255
5. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein PMID: 16956892

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Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane.

Apolipoprotein O/MICOS complex subunit Mic27 family

Expressed in all tissues examined. Up-regulated in diabetic heart.

HGNC: 28727

OMIM: 300753

KEGG: hsa:79135

STRING: 9606.ENSP00000368528

UniGene: Hs.495851