WASHC2A
WASH complex subunit 2Ais a protein in humans that is encoded by WASHC2A gene. Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission.
WASHC2A Proteins
WASHC2A Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP714470HU CSB-EP714470HU CSB-BP714470HU CSB-MP714470HU CSB-EP714470HU-B |
Recombinant Human WASH complex subunit FAM21A (FAM21A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
