VIM
VIM蛋白全稱波形蛋白，是Ⅲ型中間纖維的主要成分，構(gòu)成細(xì)胞骨架網(wǎng)絡(luò)維持細(xì)胞機(jī)械穩(wěn)定性。VIM在上皮細(xì)胞損傷修復(fù)時(shí)異常升高，促進(jìn)細(xì)胞形態(tài)改變與遷移能力，其過度表達(dá)被視為上皮-間質(zhì)轉(zhuǎn)化的標(biāo)志物，與乳腺癌、胰腺癌的侵襲轉(zhuǎn)移密切相關(guān)。在纖維化疾病領(lǐng)域，肺、肝組織中的VIM沉積與器官硬化進(jìn)程直接相關(guān)，阿爾茨海默病患者腦脊液內(nèi)也檢測到特異性片段積累。
針對VIM的治療策略多聚焦于抑制其病理聚合。小分子化合物Withaferin A從天然植物提取，可破壞VIM纖維結(jié)構(gòu)，在動(dòng)物模型中有效減緩腫瘤轉(zhuǎn)移和肺纖維化進(jìn)展，但存在肝腎毒性問題。單克隆抗體VN-18.2通過阻斷VIM與細(xì)胞膜整合素互作，已完成黑色素瘤治療的臨床前評估。近年來利用CRISPR技術(shù)敲低VIM表達(dá)改善心肌纖維化的研究引發(fā)關(guān)注，其載體遞送效率仍是轉(zhuǎn)化難點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Vimentin (VIM) (CSB-EP025857HUc7)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
VIM Recombinant Monoclonal Antibody (CSB-RA025857MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of NIH/3T3 cell with CSB-RA025857MA1HU at 1:40, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human vimentin,VIM ELISA Kit (CSB-E08982h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E08982h
規(guī)格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
VIM Antibodies
VIM for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025857GA01HU | VIM Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA573495 | VIM Antibody | Human,Mouse,Rat,Monkey | ELISA,WB,IF |
| CSB-PA084867 | Phospho-VIM (Ser56) Antibody | Human | ELISA,WB |
| CSB-PA233606 | VIM Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000431 | VIM Antibody | Human,Mouse,Rat | WB |
| CSB-PA004448 | VIM Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA004449 | VIM Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA004450 | VIM Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA004451 | VIM Antibody | Human | WB, ELISA |
| CSB-PA060073 | Phospho-VIM (Y61) Antibody | Human | WB, ELISA |
| CSB-PA060074 | Phospho-VIM (S83) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA060075 | Phospho-VIM (S56) Antibody | Human | WB, IHC, ELISA |
| CSB-PA224594 | VIM Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA200577 | VIM Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA025857LA01HU | VIM Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA025857LB01HU | VIM Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025857LC01HU | VIM Antibody, FITC conjugated | Human | |
| CSB-PA025857LD01HU | VIM Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA025857MA1HU | VIM Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
VIM for H, M, R
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA000319 | VIM Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB |
VIM Proteins
VIM Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857MO CSB-BP025857MO CSB-EP025857MO-B |
Recombinant Mouse Vimentin (Vim) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP025857MO | Recombinant Mouse Vimentin (Vim) | E.coli |
VIM Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857RA CSB-EP025857RA CSB-BP025857RA CSB-MP025857RA CSB-EP025857RA-B |
Recombinant Rat Vimentin (Vim) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857BO CSB-EP025857BO CSB-BP025857BO CSB-MP025857BO CSB-EP025857BO-B |
Recombinant Bovine Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857HU | Recombinant Human Vimentin (VIM) | Yeast |
| CSB-EP025857HU | Recombinant Human Vimentin (VIM) | E.coli |
| CSB-BP025857HU CSB-MP025857HU CSB-EP025857HU-B |
Recombinant Human Vimentin (VIM) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP025857HUc7 | Recombinant Human Vimentin (VIM) | E.coli |
VIM Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857CH CSB-EP025857CH CSB-BP025857CH CSB-MP025857CH CSB-EP025857CH-B |
Recombinant Chicken Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857PI CSB-EP025857PI CSB-BP025857PI CSB-MP025857PI CSB-EP025857PI-B |
Recombinant Pig Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857DSU CSB-EP025857DSU CSB-BP025857DSU CSB-MP025857DSU CSB-EP025857DSU-B |
Recombinant Chlorocebus aethiops Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857DXU CSB-EP025857DXU CSB-BP025857DXU CSB-MP025857DXU CSB-EP025857DXU-B |
Recombinant Cricetulus griseus Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857OEI CSB-EP025857OEI CSB-BP025857OEI CSB-MP025857OEI CSB-EP025857OEI-B |
Recombinant Oncorhynchus mykiss Vimentin (vim) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857MRG CSB-EP025857MRG CSB-BP025857MRG CSB-MP025857MRG CSB-EP025857MRG-B |
Recombinant Mesocricetus auratus Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857MOV CSB-EP025857MOV CSB-BP025857MOV CSB-MP025857MOV CSB-EP025857MOV-B |
Recombinant Macaca fascicularis Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857EQV CSB-EP025857EQV CSB-BP025857EQV CSB-MP025857EQV CSB-EP025857EQV-B |
Recombinant Pan troglodytes Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Cyprinus carpio (Common carp)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857EQE CSB-EP025857EQE CSB-BP025857EQE CSB-MP025857EQE CSB-EP025857EQE-B |
Recombinant Cyprinus carpio Vimentin (vim) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025857SH CSB-EP025857SH CSB-BP025857SH CSB-MP025857SH CSB-EP025857SH-B |
Recombinant Sheep Vimentin (VIM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VIM Proteins for MO-Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-MP025857MO | Recombinant Mouse Vimentin (Vim) | Mammalian cell |
VIM ELISA Kit
VIM ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08982h | Human vimentin,VIM ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
VIM ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14029r | Rat vimentin (VIM)ELISA Kit | serum, plasma, tissue homogenates | 5.8 ng/mL |
