VAV3
Guanine nucleotide exchange factor VAV3 is a protein in humans that is encoded by VAV3 gene. Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils.
VAV3 Antibodies
VAV3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA779366 | Phospho-VAV3 (Tyr173) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006523 | Phospho-VAV3 (Y173) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA006526 | VAV3 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA892140LA01HU | VAV3 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA892140LB01HU | VAV3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA892140LC01HU | VAV3 Antibody, FITC conjugated | Human | |
| CSB-PA892140LD01HU | VAV3 Antibody, Biotin conjugated | Human | ELISA |
VAV3 Proteins
VAV3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP889921MO CSB-EP889921MO CSB-BP889921MO CSB-MP889921MO CSB-EP889921MO-B |
Recombinant Mouse Guanine nucleotide exchange factor VAV3 (Vav3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VAV3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP892140HU CSB-EP892140HU CSB-BP892140HU CSB-MP892140HU CSB-EP892140HU-B |
Recombinant Human Guanine nucleotide exchange factor VAV3 (VAV3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
