TREM2

TREM2，即髓樣細胞觸發受體2，它是一種主要在中樞神經系統的小膠質細胞中表達的跨膜受體蛋白。TREM2通過其胞外免疫球蛋白結構域識別多種配體，包括病原體相關分子模式（PAMPs）和損傷相關分子模式（DAMPs）。其作用機制涉及與配體結合后激活下游信號通路，主要通過與DAP12結合，激活Syk激酶，進而觸發包括PI3K、PLCγ和RAS/MEK/ERK等在內的多種信號傳導途徑。這些信號通路影響小膠質細胞的吞噬功能、細胞存活、代謝平衡和炎癥反應。在生物學意義上，TREM2對維持中樞神經系統穩態、調節免疫反應和參與神經退行性疾病的發病機制具有重要作用。TREM2信號的異常激活與阿爾茨海默病等神經退行性疾病的發生發展密切相關，是當前神經科學研究的熱點之一。

熱銷產品

Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial (CSB-EP024405HUd1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TREM2 Antibody (CSB-PA024405LA01HU)

驗證數據

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA024405LA01HU at dilution of 1:100

Immunofluorescence staining of HepG2 cells with CSB-PA024405LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit (CSB-EL024405HU)

驗證數據

貨號：CSB-EL024405HU

規格：96T/48T

靈敏度：0.078 ng/mL

檢測范圍：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TREM2 Antibody

TREM2 Protein

TREM2 ELISA Kit

TREM2 Antibodies

TREM2 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA436852	TREM2 Antibody	Human,Mouse	ELISA,WB
CSB-PA024405LA01HU	TREM2 Antibody	Human	ELISA, IHC, IF
CSB-PA024405LB01HU	TREM2 Antibody, HRP conjugated	Human	ELISA
CSB-PA024405LC01HU	TREM2 Antibody, FITC conjugated	Human
CSB-PA024405LD01HU	TREM2 Antibody, Biotin conjugated	Human	ELISA

TREM2 for Mus musculus (Mouse)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA024405LA01MO	Trem2 Antibody	Mouse, Human	ELISA, WB
CSB-PA024405LD01MO	Trem2 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA024405LC01MO	Trem2 Antibody, FITC conjugated	Mouse
CSB-PA024405LB01MO	Trem2 Antibody, HRP conjugated	Mouse	ELISA

TREM2 Proteins

TREM2 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP024405MO CSB-BP024405MO CSB-EP024405MO-B	Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP024405MO	Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial	E.coli
CSB-MP024405MO	Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial	Mammalian cell

TREM2 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP024405HU	Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial	Yeast
CSB-EP024405HU	Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial	E.coli
CSB-BP024405HU CSB-EP024405HU-B	Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial	Baculovirus In Vivo Biotinylation in E.coli
CSB-MP024405HU	Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial	Mammalian cell
CSB-EP024405HUd1	Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial	E.coli