TREM2
TREM2，即髓樣細胞觸發受體2，它是一種主要在中樞神經系統的小膠質細胞中表達的跨膜受體蛋白。TREM2通過其胞外免疫球蛋白結構域識別多種配體，包括病原體相關分子模式（PAMPs）和損傷相關分子模式（DAMPs）。其作用機制涉及與配體結合后激活下游信號通路，主要通過與DAP12結合，激活Syk激酶，進而觸發包括PI3K、PLCγ和RAS/MEK/ERK等在內的多種信號傳導途徑。這些信號通路影響小膠質細胞的吞噬功能、細胞存活、代謝平衡和炎癥反應。在生物學意義上，TREM2對維持中樞神經系統穩態、調節免疫反應和參與神經退行性疾病的發病機制具有重要作用。TREM2信號的異常激活與阿爾茨海默病等神經退行性疾病的發生發展密切相關，是當前神經科學研究的熱點之一。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TREM2 Antibody (CSB-PA024405LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA024405LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA024405LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit (CSB-EL024405HU)
驗證數據
貨號：CSB-EL024405HU
規格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TREM2 Antibodies
TREM2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA436852 | TREM2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA024405LA01HU | TREM2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA024405LB01HU | TREM2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA024405LC01HU | TREM2 Antibody, FITC conjugated | Human | |
| CSB-PA024405LD01HU | TREM2 Antibody, Biotin conjugated | Human | ELISA |
TREM2 for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA024405LA01MO | Trem2 Antibody | Mouse, Human | ELISA, WB |
| CSB-PA024405LD01MO | Trem2 Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA024405LC01MO | Trem2 Antibody, FITC conjugated | Mouse | |
| CSB-PA024405LB01MO | Trem2 Antibody, HRP conjugated | Mouse | ELISA |
TREM2 Proteins
TREM2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP024405MO CSB-BP024405MO CSB-EP024405MO-B |
Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP024405MO | Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial | E.coli |
| CSB-MP024405MO | Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial | Mammalian cell |
TREM2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | Yeast |
| CSB-EP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | E.coli |
| CSB-BP024405HU CSB-EP024405HU-B |
Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | Mammalian cell |
| CSB-EP024405HUd1 | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | E.coli |
TREM2 ELISA Kit
TREM2 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL024405HU | Human Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
TREM2 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL024405MO | Mouse Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
