TLR4
TLR4全名Toll樣受體4，也被稱為CD284或hToll，是機(jī)體感知病原體入侵的重要"哨兵"。TLR4主要駐扎在免疫細(xì)胞表面，能夠敏銳識(shí)別細(xì)菌脂多糖等危險(xiǎn)信號(hào)，迅速激活防御系統(tǒng)。當(dāng)它與特定分子結(jié)合時(shí)，會(huì)聯(lián)動(dòng)細(xì)胞內(nèi)多種信號(hào)分子，促使免疫細(xì)胞釋放炎性因子，同時(shí)協(xié)調(diào)吞噬細(xì)胞清除病原體。這種快速反應(yīng)機(jī)制在對(duì)抗感染中不可或缺，但過(guò)度激活可能引發(fā)全身炎癥風(fēng)暴。
TLR4功能失衡與多種疾病密切相關(guān)。在敗血癥和急性呼吸窘迫綜合征患者中，其異常活躍會(huì)加劇組織損傷；而在某些腫瘤微環(huán)境和慢性感染中，其活性抑制又可能導(dǎo)致免疫應(yīng)答不足。近年來(lái)針對(duì)該靶點(diǎn)的藥物研發(fā)聚焦于調(diào)控其活性窗口，例如TAK-242等抑制劑曾嘗試用于膿毒癥治療，新型納米抗體則探索在自身免疫病中的應(yīng)用。部分研究團(tuán)隊(duì)正嘗試將其調(diào)控劑與化療藥物聯(lián)用，以改善腫瘤免疫治療效果。
熱銷產(chǎn)品
Recombinant Human Toll-like receptor 4 (TLR4), partial (CSB-EP023603HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TLR4 Recombinant Monoclonal Antibody (CSB-RA023603MA1HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing Hela cells stained with CSB-RA023603MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human toll-like receptor 4,TLR4 ELISA Kit (CSB-E12954h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E12954h
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測(cè)范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TLR4 Antibodies
TLR4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023603GA01HU | TLR4 Antibody | Human,Mouse,Rat,Bovin | ELISA,WB |
| CSB-PA001434 | TLR4 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA080181 | TLR4 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA237733 | TLR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA902590 | TLR4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA776633 | TLR4 Antibody | Human | ELISA,IHC |
| CSB-PA585936 | TLR4 Antibody | Human | ELISA,IHC |
| CSB-RA023603MA1HU | TLR4 Recombinant Monoclonal Antibody | Human | ELISA, FC |
TLR4 Proteins
TLR4 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603CA CSB-EP023603CA CSB-BP023603CA CSB-MP023603CA CSB-EP023603CA-B |
Recombinant Cat Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603HU CSB-EP023603HU CSB-BP023603HU CSB-MP023603HU CSB-EP023603HU-B |
Recombinant Human Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023603HU1 | Recombinant Human Toll-like receptor 4 (TLR4), partial | E.coli |
| CSB-BP023603HU1 | Recombinant Human Toll-like receptor 4 (TLR4), partial | Baculovirus |
TLR4 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603PI CSB-EP023603PI CSB-BP023603PI CSB-MP023603PI CSB-EP023603PI-B |
Recombinant Pig Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603GGZ CSB-EP023603GGZ CSB-BP023603GGZ CSB-MP023603GGZ CSB-EP023603GGZ-B |
Recombinant Gorilla gorilla gorilla Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603EXP CSB-EP023603EXP CSB-BP023603EXP CSB-MP023603EXP CSB-EP023603EXP-B |
Recombinant Pongo pygmaeus Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603BO CSB-EP023603BO CSB-BP023603BO CSB-MP023603BO CSB-EP023603BO-B |
Recombinant Bovine Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603HO CSB-EP023603HO CSB-BP023603HO CSB-MP023603HO CSB-EP023603HO-B |
Recombinant Horse Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603RA CSB-EP023603RA CSB-BP023603RA CSB-MP023603RA CSB-EP023603RA-B |
Recombinant Rat Toll-like receptor 4 (Tlr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023603RA | Recombinant Rat Toll-like receptor 4 (Tlr4), partial | in vitro E.coli expression system |
TLR4 Proteins for Papio anubis (Olive baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603ERI CSB-EP023603ERI CSB-BP023603ERI CSB-MP023603ERI CSB-EP023603ERI-B |
Recombinant Papio anubis Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603MO | Recombinant Mouse Toll-like receptor 4 (Tlr4), partial | Yeast |
| CSB-EP023603MO CSB-BP023603MO CSB-MP023603MO CSB-EP023603MO-B |
Recombinant Mouse Toll-like receptor 4 (Tlr4), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603EQU CSB-EP023603EQU CSB-BP023603EQU CSB-MP023603EQU CSB-EP023603EQU-B |
Recombinant Pan paniscus Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603DXU CSB-EP023603DXU CSB-BP023603DXU CSB-MP023603DXU CSB-EP023603DXU-B |
Recombinant Cricetulus griseus Toll-like receptor 4 (TLR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 Proteins for Boselaphus tragocamelus (Nilgai)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023603BUN CSB-EP023603BUN CSB-BP023603BUN CSB-MP023603BUN CSB-EP023603BUN-B |
Recombinant Boselaphus tragocamelus Toll-like receptor 4 (TLR4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR4 ELISA Kit
TLR4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12954h | Human toll-like receptor 4,TLR4 ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
TLR4 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14275m | Mouse Soluble Toll-like Receptor 4,sTLR4 ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
TLR4 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E15822r | Rat toll-like receptor 4 (TLR4) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.156 ng/mL |
