THBD

血栓調(diào)節(jié)蛋白（Thrombomodulin），簡(jiǎn)稱THBD，是一種存在于血管內(nèi)皮細(xì)胞表面的糖蛋白，能夠與凝血酶形成1:1的化學(xué)計(jì)量復(fù)合物。該蛋白在凝血調(diào)節(jié)中發(fā)揮著關(guān)鍵作用，它能夠促進(jìn)蛋白C轉(zhuǎn)化為其活化形式蛋白Ca，進(jìn)而抑制凝血酶的產(chǎn)生，并下調(diào)補(bǔ)體激活。THBD除了在凝血系統(tǒng)中發(fā)揮作用外，還參與調(diào)節(jié)免疫反應(yīng)，并可能與細(xì)胞分化或炎癥有關(guān)。
THBD基因的多態(tài)性可能與血栓栓塞性疾病相關(guān)。THBD蛋白的表達(dá)主要集中于血管內(nèi)皮細(xì)胞，但在其他細(xì)胞類型中也有表達(dá)，例如角質(zhì)形成細(xì)胞、成骨細(xì)胞和巨噬細(xì)胞等。在血栓調(diào)節(jié)蛋白功能降低的情況下，血管內(nèi)皮細(xì)胞損傷后會(huì)導(dǎo)致大量血栓形成和高凝狀態(tài)，從而增加血栓栓塞性疾病的風(fēng)險(xiǎn)。
目前，針對(duì)THBD蛋白的藥物研發(fā)主要集中在抗血栓領(lǐng)域。例如，一些研究正在探索利用THBD蛋白作為抗血栓藥物的靶點(diǎn)，以開發(fā)新型的抗血栓藥物。此外，也有一些研究關(guān)注THBD蛋白在免疫調(diào)節(jié)中的作用，并探索其作為免疫調(diào)節(jié)藥物的潛力。

熱銷產(chǎn)品

Recombinant Human Thrombomodulin (THBD), partial (CSB-EP023486HU2)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

THBD Recombinant Monoclonal Antibody (CSB-RA222792A0HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA222792A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

THBD Antibody

THBD Protein

THBD ELISA Kit

THBD Antibodies

THBD for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA023486GA01HU	THBD Antibody	Human	ELISA,WB,IHC
CSB-PA179250	THBD Antibody	Human	ELISA,WB
CSB-PA050256	THBD Antibody	Human	WB, ELISA
CSB-PA023486DSR1HU	THBD Antibody	Human, Mouse, Rat	ELISA, WB
CSB-PA023486DSR2HU	THBD Antibody	Human	ELISA, IHC
CSB-RA222792A0HU	THBD Recombinant Monoclonal Antibody	Human	ELISA, IHC

THBD Proteins

THBD Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP023486MO1 CSB-EP023486MO1 CSB-BP023486MO1 CSB-MP023486MO1 CSB-EP023486MO1-B	Recombinant Mouse Thrombomodulin (Thbd), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023486MO	Recombinant Mouse Thrombomodulin (Thbd)	in vitro E.coli expression system

THBD Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP023486BO CSB-EP023486BO CSB-BP023486BO CSB-MP023486BO CSB-EP023486BO-B	Recombinant Bovine Thrombomodulin (THBD), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

THBD Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP023486HU1 CSB-BP023486HU1 CSB-MP023486HU1 CSB-EP023486HU1-B	Recombinant Human Thrombomodulin (THBD), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023486HU	Recombinant Human Thrombomodulin (THBD)	in vitro E.coli expression system
CSB-EP023486HU2	Recombinant Human Thrombomodulin (THBD), partial	E.coli
CSB-EP023486HU1	Recombinant Human Thrombomodulin (THBD), partial	E.coli

THBD Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP023486DO CSB-EP023486DO CSB-BP023486DO CSB-MP023486DO CSB-EP023486DO-B	Recombinant Dog Thrombomodulin (THBD), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

THBD Proteins for Saimiri sciureus (Common squirrel monkey)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP023486SWD CSB-EP023486SWD CSB-BP023486SWD CSB-MP023486SWD CSB-EP023486SWD-B	Recombinant Saimiri sciureus Thrombomodulin (THBD), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli