SRD5A2
SRD5A2，即類固醇5α-還原酶2，別名3-氧-5α-類固醇4-脫氫酶2、II型5α-還原酶等。它是一種微粒體酶，主要在人體中由SRD5A2基因編碼，高表達(dá)于對雄激素敏感的組織如前列腺。SRD5A2的作用機(jī)制是通過催化睪酮轉(zhuǎn)化為雙氫睪酮(DHT)，DHT與毛囊雄激素受體結(jié)合能力更強(qiáng)，這一過程對于性分化和雄激素生理學(xué)具有重要作用。此外，SRD5A2還參與了其他類固醇激素的代謝過程。SRD5A2在生物學(xué)上的意義非常廣泛，它不僅參與調(diào)節(jié)生殖系統(tǒng)的正常發(fā)育和功能，還與多種疾病相關(guān)。例如，SRD5A2基因的突變可導(dǎo)致男性假兩性畸形，特別是假陰道性會陰型尿道下裂。此外，SRD5A2的活性改變與前列腺癌的發(fā)展有關(guān)，其異常表達(dá)可能促進(jìn)前列腺癌的進(jìn)展。在藥物研究方面，SRD5A2抑制劑如非那雄胺和杜特列特等藥物已廣泛應(yīng)用于治療前列腺增生等疾病。因此，SRD5A2是性激素相關(guān)疾病研究和治療中的一個重要靶點。
熱銷產(chǎn)品
Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial (CSB-EP022654HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2) ELISA kit (CSB-EL022654HU)
驗證數(shù)據(jù)
貨號：CSB-EL022654HU
規(guī)格：96T/48T
靈敏度：6 pg/mL
檢測范圍：12 pg/mL-2400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SRD5A2 Proteins
SRD5A2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022654HU1 CSB-BP022654HU1 CSB-MP022654HU1 CSB-EP022654HU1-B |
Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF022654HU | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) | in vitro E.coli expression system |
| CSB-EP022654HU1 | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial | E.coli |
| CSB-MP022654HU | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)-VLPs | Mammalian cell |
SRD5A2 ELISA Kit
SRD5A2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL022654HU | Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2) ELISA kit | serum, plasma, tissue homogenates | 6 pg/mL |
