RUVBL2
RUVBL2，別名RVB2、TIH2、ECP51、TIP48、CGI-46、ECP-51、INO80J、REPTIN、TIP49B、TAP54-beta，在人類細(xì)胞中廣泛表達(dá)，屬于AAA+ATPase家族成員。RUVBL2的作用機(jī)制涉及其ATP酶活性，參與多種細(xì)胞過程，包括染色質(zhì)重塑、轉(zhuǎn)錄調(diào)控、葡萄糖轉(zhuǎn)運(yùn)以及大分子復(fù)合物的組裝。RUVBL2還起到轉(zhuǎn)錄調(diào)控的作用，通過調(diào)節(jié)與軸突生成和突觸小泡相關(guān)的基因表達(dá)來調(diào)控突觸可塑性和突觸傳遞，進(jìn)而影響食欲和體重控制。RUVBL2與多種疾病相關(guān)，包括脊髓性肌肉萎縮、遠(yuǎn)端遺傳性運(yùn)動神經(jīng)元病、先天性角化不良等。
熱銷產(chǎn)品
Recombinant Human RuvB-like 2 (RUVBL2) (CSB-EP897459HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
RUVBL2 Antibody (CSB-PA897459LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: K562 whole cell lysate, HepG2 whole cell lysate, Rat liver tissue, Mouse brain tissue
All lanes: RUVBL2 antibody at 2.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 47 kDa
Observed band size: 52 kDa
IHC image of CSB-PA897459LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA897459LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
RUVBL2 Antibodies
RUVBL2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA020599GA01HU | RUVBL2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA897459LA01HU | RUVBL2 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA897459LB01HU | RUVBL2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA897459LC01HU | RUVBL2 Antibody, FITC conjugated | Human | |
| CSB-PA897459LD01HU | RUVBL2 Antibody, Biotin conjugated | Human | ELISA |
RUVBL2 Proteins
RUVBL2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP897459HU CSB-BP897459HU CSB-MP897459HU CSB-EP897459HU-B |
Recombinant Human RuvB-like 2 (RUVBL2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP897459HU | Recombinant Human RuvB-like 2 (RUVBL2) | E.coli |
