ROS1
ROS1，即c-ros肉瘤致癌因子-受體酪氨酸激酶，別名CD74-ROS1、EZR-ROS1、SLC34A2-ROS1等，這些別名通常表示ROS1基因與其他基因發生融合的形式。ROS1基因定位于人類6號染色體長臂，屬于酪氨酸激酶胰島素受體基因，由胞內激酶區、跨膜區及胞外區三部分組成，編碼具有酪氨酸激酶活性的跨膜蛋白 。ROS1的作用機制涉及其作為細胞表面受體的功能，當接收到外部特定信息后活化，并傳遞信號到細胞內部，指導細胞有序地生長和增殖。若ROS1基因發生致癌變異，會激活其下游通路的信號，造成細胞過度地生長及增殖，驅動腫瘤的發生。ROS1主要參與的信號通路包括RAS-RAF-MEK-ERK（MAPK）、PI3K-AKT-mTOR等 。在生物學意義上，ROS1基因融合在多種腫瘤中被認為是致癌因素，特別是在非小細胞肺癌中，ROS1融合基因型肺癌的發病率較低，但具有獨特的臨床病理特征。ROS1融合基因的發現為靶向治療提供了新的治療靶點，已有多種針對ROS1的小分子抑制劑在臨床試驗中顯示出療效，如克唑替尼等 。
熱銷產品
ROS1 Antibody (CSB-PA020072LA01HU)
驗證數據
Immunofluorescence staining of Hela cells with CSB-PA020072LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ROS1 Antibodies
ROS1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA185342 | ROS1 Antibody | Human | ELISA,IHC |
| CSB-PA020072LA01HU | ROS1 Antibody | Human | ELISA, IF |
| CSB-PA020072LB01HU | ROS1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA020072LC01HU | ROS1 Antibody, FITC conjugated | Human | |
| CSB-PA020072LD01HU | ROS1 Antibody, Biotin conjugated | Human | ELISA |
ROS1 for Arabidopsis thaliana
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA874445LA01DOA | ROS1 Antibody | Arabidopsis thaliana | ELISA |
| CSB-PA874445LB01DOA | ROS1 Antibody, HRP conjugated | Arabidopsis thaliana | ELISA |
| CSB-PA874445LC01DOA | ROS1 Antibody, FITC conjugated | Arabidopsis thaliana | |
| CSB-PA874445LD01DOA | ROS1 Antibody, Biotin conjugated | Arabidopsis thaliana | ELISA |
ROS1 Proteins
ROS1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020072HU CSB-EP020072HU CSB-BP020072HU CSB-MP020072HU CSB-EP020072HU-B |
Recombinant Human Proto-oncogene tyrosine-protein kinase ROS (ROS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ROS1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020072CH CSB-EP020072CH CSB-BP020072CH CSB-MP020072CH CSB-EP020072CH-B |
Recombinant Chicken Proto-oncogene tyrosine-protein kinase ROS (ROS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ROS1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP737174RA CSB-EP737174RA CSB-BP737174RA CSB-MP737174RA CSB-EP737174RA-B |
Recombinant Rat Proto-oncogene tyrosine-protein kinase ROS (Ros1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ROS1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP755276MO CSB-EP755276MO CSB-BP755276MO CSB-MP755276MO CSB-EP755276MO-B |
Recombinant Mouse Proto-oncogene tyrosine-protein kinase ROS (Ros1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ROS1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP874445DOA CSB-BP874445DOA CSB-MP874445DOA CSB-EP874445DOA-B |
Recombinant Arabidopsis thaliana Protein ROS1 (ROS1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP874445DOA | Recombinant Arabidopsis thaliana Protein ROS1 (ROS1), partial | E.coli |
