RNASEL
2-5A-dependent ribonuclease is a protein in humans that is encoded by RNASEL gene. Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis
RNASEL Antibodies
RNASEL for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA313223LD01HU | RNASEL Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA313223LC01HU | RNASEL Antibody, FITC conjugated | Human | |
| CSB-PA313223LB01HU | RNASEL Antibody, HRP conjugated | Human | ELISA |
| CSB-PA313223LA01HU | RNASEL Antibody | Human | ELISA, IHC |
RNASEL Proteins
RNASEL Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP313223HU CSB-BP313223HU CSB-MP313223HU CSB-EP313223HU-B |
Recombinant Human 2-5A-dependent ribonuclease (RNASEL) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP313223HU1 | Recombinant Human 2-5A-dependent ribonuclease (RNASEL), partial | E.coli |
| CSB-EP313223HU | Recombinant Human 2-5A-dependent ribonuclease (RNASEL) | E.coli |
| CSB-EP313223HUe0 | Recombinant Human 2-5A-dependent ribonuclease (RNASEL) | E.coli |
RNASEL Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP313237MO CSB-EP313237MO CSB-BP313237MO CSB-MP313237MO CSB-EP313237MO-B |
Recombinant Mouse 2-5A-dependent ribonuclease (Rnasel), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
