PTTG1
Securin is a protein in humans that is encoded by PTTG1 gene. Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed.
PTTG1 Antibodies
PTTG1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019074GA01HU | PTTG1 Antibody | Human,Mouse,Rat | ELISA,IF |
| CSB-PA443065 | PTTG1 Antibody | Human | ELISA,WB,IF |
| CSB-PA003885 | PTTG1 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA989924 | PTTG1 Antibody | Human | ELISA,IHC |
| CSB-PA282697 | PTTG1 Antibody | Human | ELISA,IHC |
| CSB-PA019074LA01HU | PTTG1 Antibody | Human | ELISA, WB |
| CSB-PA019074LB01HU | PTTG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA019074LD01HU | PTTG1 Antibody, Biotin conjugated | Human | ELISA |
PTTG1 Proteins
PTTG1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019074RA CSB-EP019074RA CSB-BP019074RA CSB-MP019074RA CSB-EP019074RA-B |
Recombinant Rat Securin (Pttg1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTTG1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019074HU CSB-EP019074HU CSB-BP019074HU CSB-MP019074HU CSB-EP019074HU-B |
Recombinant Human Securin (PTTG1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTTG1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019074GGZ CSB-EP019074GGZ CSB-BP019074GGZ CSB-MP019074GGZ CSB-EP019074GGZ-B |
Recombinant Gorilla gorilla gorilla Securin (PTTG1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTTG1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019074EQV CSB-EP019074EQV CSB-BP019074EQV CSB-MP019074EQV CSB-EP019074EQV-B |
Recombinant Pan troglodytes Securin (PTTG1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTTG1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP662271BO CSB-EP662271BO CSB-BP662271BO CSB-MP662271BO CSB-EP662271BO-B |
Recombinant Bovine Securin (PTTG1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTTG1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP860610PI CSB-EP860610PI CSB-BP860610PI CSB-MP860610PI CSB-EP860610PI-B |
Recombinant Pig Securin (PTTG1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTTG1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP887426MO CSB-EP887426MO CSB-BP887426MO CSB-MP887426MO CSB-EP887426MO-B |
Recombinant Mouse Securin (Pttg1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTTG1 ELISA Kit
PTTG1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL019074HU | Human Securin(PTTG1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 7.8 pg/mL |
