PTGER4
PTGER4，全稱為前列腺素E受體4（亞型EP4），是一種在人體內(nèi)發(fā)揮重要作用的蛋白質(zhì)。該蛋白屬于G蛋白偶聯(lián)受體家族，能夠與前列腺素E2（PGE2）結(jié)合，從而參與多種生理和病理過(guò)程。PTGER4的常見(jiàn)別名包括EP4、EP4R、Ptger、PTGER2、PTGER4和Ptgerep4等。
PTGER4蛋白在人體內(nèi)的主要功能是作為PGE2的受體，介導(dǎo)PGE2引發(fā)的細(xì)胞信號(hào)傳導(dǎo)。研究表明，PTGER4激動(dòng)劑能夠刺激胰島α和β細(xì)胞分泌胰高血糖素和胰島素，對(duì)血糖調(diào)節(jié)具有重要作用。此外，PTGER4還參與調(diào)節(jié)腎血流動(dòng)力學(xué)、腸道上皮細(xì)胞轉(zhuǎn)運(yùn)、腎上腺醛固酮分泌以及子宮功能等。
PTGER4蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)。例如，研究表明PTGER4激動(dòng)劑能夠促進(jìn)胰島α和β細(xì)胞分泌胰高血糖素和胰島素，對(duì)糖尿病的治療具有潛在價(jià)值。此外，PTGER4還與骨質(zhì)疏松癥、皮膚免疫應(yīng)答等疾病相關(guān)。
熱銷(xiāo)產(chǎn)品
PTGER4 Antibody (CSB-PA018973LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat liver tissue, Rat kidney tissue
All lanes: PTGER4 antibody at 3.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA018973LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
PTGER4 Antibodies
PTGER4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002354 | PTGER4 Antibody | Human | WB, IF, ELISA |
| CSB-PA826092 | PTGER4 Antibody | Human | ELISA,WB |
| CSB-PA949253 | PTGER4 Antibody | Human | ELISA,WB |
| CSB-PA018973LA01HU | PTGER4 Antibody | Human, Rat | ELISA, WB, IF |
| CSB-PA018973LB01HU | PTGER4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018973LC01HU | PTGER4 Antibody, FITC conjugated | Human |
PTGER4 Proteins
PTGER4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018973HU1 CSB-EP018973HU1 CSB-BP018973HU1 CSB-MP018973HU1 CSB-EP018973HU1-B |
Recombinant Human Prostaglandin E2 receptor EP4 subtype (PTGER4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018973HU | Recombinant Human Prostaglandin E2 receptor EP4 subtype (PTGER4) | in vitro E.coli expression system |
PTGER4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018973MO1 CSB-BP018973MO1 CSB-MP018973MO1 CSB-EP018973MO1-B |
Recombinant Mouse Prostaglandin E2 receptor EP4 subtype (Ptger4), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018973MO | Recombinant Mouse Prostaglandin E2 receptor EP4 subtype (Ptger4) | in vitro E.coli expression system |
PTGER4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018973RA1 CSB-EP018973RA1 CSB-BP018973RA1 CSB-MP018973RA1 CSB-EP018973RA1-B |
Recombinant Rat Prostaglandin E2 receptor EP4 subtype (Ptger4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018973RA | Recombinant Rat Prostaglandin E2 receptor EP4 subtype (Ptger4) | in vitro E.coli expression system |
PTGER4 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP630694RB1 CSB-EP630694RB1 CSB-BP630694RB1 CSB-MP630694RB1 CSB-EP630694RB1-B |
Recombinant Rabbit Prostaglandin E2 receptor EP4 subtype (PTGER4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF630694RB | Recombinant Rabbit Prostaglandin E2 receptor EP4 subtype (PTGER4) | in vitro E.coli expression system |
PTGER4 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP822095EQV1 CSB-EP822095EQV1 CSB-BP822095EQV1 CSB-MP822095EQV1 CSB-EP822095EQV1-B |
Recombinant Pan troglodytes Prostaglandin E2 receptor EP4 subtype (PTGER4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF822095EQV | Recombinant Pan troglodytes Prostaglandin E2 receptor EP4 subtype (PTGER4) | in vitro E.coli expression system |
PTGER4 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP822647BO1 CSB-EP822647BO1 CSB-BP822647BO1 CSB-MP822647BO1 CSB-EP822647BO1-B |
Recombinant Bovine Prostaglandin E2 receptor EP4 subtype (PTGER4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF822647BO | Recombinant Bovine Prostaglandin E2 receptor EP4 subtype (PTGER4) | in vitro E.coli expression system |
