PTAFR
血小板激活因子受體（Platelet-Activating Factor Receptor，PAFR）是一種G蛋白偶聯(lián)受體，廣泛分布于血小板、中性粒細(xì)胞及血管內(nèi)皮細(xì)胞表面。該受體因介導(dǎo)炎癥級聯(lián)反應(yīng)而聞名，當(dāng)與配體PAF結(jié)合后，可觸發(fā)細(xì)胞內(nèi)鈣離子釋放并激活磷脂酶C，進(jìn)而促進(jìn)血管通透性增高、白細(xì)胞趨化及血小板活化。其異常活化與急性呼吸窘迫綜合征、過敏性休克、動脈粥樣硬化等病理過程密切相關(guān)，在膿毒癥中常作為促炎介質(zhì)加劇全身炎癥反應(yīng)。
目前全球已開發(fā)多款PAFR拮抗劑，如昔帕芬旦（TCV-309）和來帕泛（Lexipafant）曾進(jìn)入敗血癥臨床試驗(yàn)，但因療效未達(dá)預(yù)期而終止。近年研究轉(zhuǎn)向該受體在腫瘤微環(huán)境中的作用，發(fā)現(xiàn)其通過調(diào)控NF-κB通路促進(jìn)乳腺癌轉(zhuǎn)移，相關(guān)小分子抑制劑正在臨床前評估中。某些抗組胺藥物被發(fā)現(xiàn)具有非特異性PAFR阻斷效應(yīng)，這為哮喘等過敏性疾病治療提供了新的聯(lián)合用藥思路。
熱銷產(chǎn)品
PTAFR Antibody (CSB-PA018946LA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: PTAFR antibody at 4µg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018946LA01HU at dilution of 1:100
Immunofluorescent analysis of A431 cells using CSB-PA018946LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of HepG2 cells using CSB-PA018946LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PTAFR Antibodies
PTAFR for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA040050 | PTAFR Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA109839 | PTAFR Antibody | Human | ELISA,IHC |
| CSB-PA018946LA01HU | PTAFR Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA018946LB01HU | PTAFR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018946LC01HU | PTAFR Antibody, FITC conjugated | Human | |
| CSB-PA018946LD01HU | PTAFR Antibody, Biotin conjugated | Human | ELISA |
PTAFR Proteins
PTAFR Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946GU1 CSB-EP018946GU1 CSB-BP018946GU1 CSB-MP018946GU1 CSB-EP018946GU1-B |
Recombinant Guinea pig Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946GU | Recombinant Guinea pig Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946HU1 CSB-EP018946HU1 CSB-BP018946HU1 CSB-MP018946HU1 CSB-EP018946HU1-B |
Recombinant Human Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946HU | Recombinant Human Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946RA1 CSB-EP018946RA1 CSB-BP018946RA1 CSB-MP018946RA1 CSB-EP018946RA1-B |
Recombinant Rat Platelet-activating factor receptor (Ptafr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946RA | Recombinant Rat Platelet-activating factor receptor (Ptafr) | in vitro E.coli expression system |
PTAFR Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946MOW1 CSB-EP018946MOW1 CSB-BP018946MOW1 CSB-MP018946MOW1 CSB-EP018946MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946MOW | Recombinant Macaca mulatta (Rhesus macaque) Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946MO1 CSB-EP018946MO1 CSB-BP018946MO1 CSB-MP018946MO1 CSB-EP018946MO1-B |
Recombinant Mouse Platelet-activating factor receptor (Ptafr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946MO | Recombinant Mouse Platelet-activating factor receptor (Ptafr) | in vitro E.coli expression system |
PTAFR Proteins for Capra hircus (Goat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946GO1 CSB-EP018946GO1 CSB-BP018946GO1 CSB-MP018946GO1 CSB-EP018946GO1-B |
Recombinant Goat Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946GO | Recombinant Goat Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946BO1 CSB-EP018946BO1 CSB-BP018946BO1 CSB-MP018946BO1 CSB-EP018946BO1-B |
Recombinant Bovine Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946BO | Recombinant Bovine Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018946PI1 CSB-EP018946PI1 CSB-BP018946PI1 CSB-MP018946PI1 CSB-EP018946PI1-B |
Recombinant Pig Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946PI | Recombinant Pig Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
