POLA1
POLA1 is a protein in humans that is encoded by POLA1 gene. Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNADNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses.
POLA1 Antibodies
POLA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA156369 | POLA1 Antibody | Human | ELISA,WB |
| CSB-PA002170 | POLA1 Antibody | Human | WB, ELISA |
POLA1 Proteins
POLA1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018300MO CSB-EP018300MO CSB-BP018300MO CSB-MP018300MO CSB-EP018300MO-B |
Recombinant Mouse DNA polymerase alpha catalytic subunit (Pola1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018300HU CSB-EP018300HU CSB-BP018300HU CSB-MP018300HU CSB-EP018300HU-B |
Recombinant Human DNA polymerase alpha catalytic subunit (POLA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018300RA CSB-EP018300RA CSB-BP018300RA CSB-MP018300RA CSB-EP018300RA-B |
Recombinant Rat DNA polymerase alpha catalytic subunit (Pola1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA1 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP700878DKK CSB-EP700878DKK CSB-BP700878DKK CSB-MP700878DKK CSB-EP700878DKK-B |
Recombinant Dictyostelium discoideum DNA polymerase alpha catalytic subunit (pola1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP875295XBE CSB-EP875295XBE CSB-BP875295XBE CSB-MP875295XBE CSB-EP875295XBE-B |
Recombinant Xenopus laevis DNA polymerase alpha catalytic subunit (pola1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
