PLAUR
尿激酶型纖溶酶原激活物受體（PLAUR，又稱uPAR或CD87）是一種錨定于細胞膜表面的糖蛋白受體，其核心功能是通過與尿激酶（uPA）結合，激活纖溶酶原轉化為纖溶酶，進而觸發(fā)細胞外基質(zhì)降解酶類的級聯(lián)反應。這一過程在組織重塑、傷口愈合中起關鍵作用，但也被發(fā)現(xiàn)與惡性腫瘤的侵襲轉移密切相關。臨床研究顯示，PLAUR在乳腺癌、結直腸癌等多種實體瘤中高表達，其水平升高常提示患者預后不良。該受體還能與整合素等跨膜蛋白協(xié)同調(diào)控細胞遷移，參與動脈粥樣硬化斑塊形成及類風濕性關節(jié)炎的病理進程。
近年來針對PLAUR的藥物開發(fā)聚焦于阻斷uPA-uPAR相互作用，例如單抗類藥物ATN-658已在動物模型中顯著抑制腫瘤轉移。小分子抑制劑如upain-1通過干擾受體二聚化降低癌細胞侵襲能力，目前處于臨床前研究階段。部分聯(lián)合治療方案嘗試將uPAR靶向藥物與傳統(tǒng)化療聯(lián)用，初步數(shù)據(jù)顯示可增強抗腫瘤效果并減少耐藥性，但尚未進入三期臨床試驗。
熱銷產(chǎn)品
Recombinant Human Urokinase plasminogen activator surface receptor (PLAUR) (CSB-EP018122HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLAUR Recombinant Monoclonal Antibody (CSB-RA018122MA1HU)
驗證數(shù)據(jù)
Immunofluorescence staining of hela cell with CSB-RA018122MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
Immunofluorescence staining of SH-SY5Y cell with CSB-RA018122MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
Overlay Peak curve showing Hela cells surface stained with CSB-RA018122MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,026 events was performed.
PLAUR Antibodies
PLAUR for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA018122LD01RA | Plaur Antibody, Biotin conjugated | Rat | ELISA |
| CSB-PA018122LA01RA | Plaur Antibody | Rat, Human | ELISA, WB |
PLAUR for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA018122GA01HU | PLAUR Antibody | Human | ELISA,WB |
| CSB-PA07505A0Rb | PLAUR Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA236241 | PLAUR Antibody | Human | ELISA,WB,IHC |
| CSB-PA628429 | PLAUR Antibody | Human | ELISA,WB,IHC |
| CSB-RA018122MA1HU | PLAUR Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
PLAUR Proteins
PLAUR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018122HU CSB-BP018122HU CSB-MP018122HU CSB-EP018122HU-B |
Recombinant Human Urokinase plasminogen activator surface receptor (PLAUR) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018122HU | Recombinant Human Urokinase plasminogen activator surface receptor (PLAUR) | E.coli |
PLAUR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018122MO CSB-EP018122MO CSB-BP018122MO CSB-EP018122MO-B |
Recombinant Mouse Urokinase plasminogen activator surface receptor (Plaur), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
PLAUR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018122RA | Recombinant Rat Urokinase plasminogen activator surface receptor (Plaur) | Yeast |
| CSB-EP018122RA | Recombinant Rat Urokinase plasminogen activator surface receptor (Plaur) | E.coli |
| CSB-BP018122RA CSB-MP018122RA CSB-EP018122RA-B |
Recombinant Rat Urokinase plasminogen activator surface receptor (Plaur) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLAUR Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP313189BO CSB-EP313189BO CSB-BP313189BO CSB-MP313189BO CSB-EP313189BO-B |
Recombinant Bovine Urokinase plasminogen activator surface receptor (PLAUR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLAUR Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP861934MOV CSB-EP861934MOV CSB-BP861934MOV CSB-MP861934MOV CSB-EP861934MOV-B |
Recombinant Macaca fascicularis Urokinase plasminogen activator surface receptor (PLAUR) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLAUR Proteins for Aotus trivirgatus (Night monkey) (Douroucouli)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP872378DNI CSB-EP872378DNI CSB-BP872378DNI CSB-MP872378DNI CSB-EP872378DNI-B |
Recombinant Aotus trivirgatus Urokinase plasminogen activator surface receptor (PLAUR) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLAUR Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP884384DSU CSB-EP884384DSU CSB-BP884384DSU CSB-MP884384DSU CSB-EP884384DSU-B |
Recombinant Chlorocebus aethiops Urokinase plasminogen activator surface receptor (PLAUR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLAUR Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP887898EQV CSB-EP887898EQV CSB-BP887898EQV CSB-MP887898EQV CSB-EP887898EQV-B |
Recombinant Pan troglodytes Urokinase plasminogen activator surface receptor (PLAUR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLAUR ELISA Kit
PLAUR ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04752h | Human Urokinase-type Plasminogen Activator Receptor,PLAUR/uPAR ELISA kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
PLAUR ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07366r | Rat Urokinase-type Plasminogen Activator Receptor,PLAUR/uPAR ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
