PECAM1
血小板內皮細胞黏附分子-1（PECAM1）又稱CD31或EndoCAM，是一種跨膜糖蛋白，主要表達于血管內皮細胞、血小板及部分免疫細胞表面。PECAM1通過同源或異源分子結合介導細胞間黏附，參與調控血管通透性、炎癥反應中白細胞的跨內皮遷移以及血管生成過程。其胞內段酪氨酸殘基磷酸化后可激活下游信號，與PI3K/AKT、MAPK等通路存在關聯，在維持血管穩態中起關鍵作用。
PECAM1異常表達與動脈粥樣硬化斑塊形成、血栓性疾病及腫瘤血管生成密切相關。在動脈粥樣硬化中，其介導的單核細胞浸潤加速斑塊進展；在腫瘤微環境中則可能通過調控血管新生促進癌癥轉移。目前針對PECAM1的治療策略多處于臨床前階段，包括開發阻斷其介導白細胞遷移的單克隆抗體，以及利用其作為靶點構建腫瘤血管靶向藥物遞送系統。
熱銷產品
PECAM1 Recombinant Monoclonal Antibody (CSB-RA017767MA1HU)
驗證數據
Western Blot
Positive WB detected in: THP-1 whole cell lysate, JK whole cell lysate
All lanes: PECAM1 antibody at 1:500
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 82-140 kDa
Observed band size: 140 kDa
Overlay Peak curve showing THP-1 cells stained with CSB-RA017767MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit (CSB-E08133h)
驗證數據
貨號：CSB-E08133h
規格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
PECAM1 Antibodies
PECAM1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017767GA01HU | PECAM1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA616412 | PECAM1 Antibody | Human | ELISA,WB |
| CSB-PA116016 | PECAM1 (Ab-713) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA851852 | PECAM1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA666102 | Phospho-PECAM1 (Y713) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA777657 | PECAM1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA982317 | PECAM1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA085447 | PECAM1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA929097 | PECAM1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA022257 | PECAM1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA116222 | PECAM1 Antibody | Human | WB,ELISA |
| CSB-PA017767LA01HU | PECAM1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| CSB-PA017767LB01HU | PECAM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017767LC01HU | PECAM1 Antibody, FITC conjugated | Human | |
| CSB-PA017767LD01HU | PECAM1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA017767A0HU | CD31 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
| CSB-MA017767A0m | CD31 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
| CSB-RA017767MA1HU | PECAM1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, FC |
PECAM1 Proteins
PECAM1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017767BO1 CSB-EP017767BO1 CSB-BP017767BO1 CSB-MP017767BO1 CSB-EP017767BO1-B |
Recombinant Bovine Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF017767BO | Recombinant Bovine Platelet endothelial cell adhesion molecule (PECAM1) | in vitro E.coli expression system |
PECAM1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017767HU1 CSB-EP017767HU1 CSB-BP017767HU1 CSB-MP017767HU1 CSB-EP017767HU1-B |
Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF017767HU | Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1) | in vitro E.coli expression system |
PECAM1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP668776RA CSB-EP668776RA CSB-BP668776RA CSB-MP668776RA CSB-EP668776RA-B |
Recombinant Rat Platelet endothelial cell adhesion molecule (Pecam1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PECAM1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP839162PI CSB-EP839162PI CSB-BP839162PI CSB-MP839162PI CSB-EP839162PI-B |
Recombinant Pig Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PECAM1 ELISA Kit
PECAM1 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08135m | Mouse soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma | 0.78 pg/mL |
PECAM1 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08134r | Rat soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
PECAM1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08133h | Human soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma, cell culture supernates | 7.8 pg/mL |
