PDIA3
PDIA3，即蛋白質(zhì)二硫鍵異構(gòu)酶A3（Protein disulfide-isomerase A3），別名58 kDa glucose-regulated protein、58 kDa microsomal protein (p58)、Disulfide isomerase ER-60。它屬于蛋白質(zhì)二硫鍵異構(gòu)酶(PDI)家族的成員，是一種在內(nèi)質(zhì)網(wǎng)中催化二硫鍵形成的酶，對(duì)蛋白質(zhì)折疊和質(zhì)量控制起著至關(guān)重要的作用。PDIA3作為分子伴侶，參與蛋白質(zhì)的正確折疊、組裝和分泌，尤其在細(xì)胞應(yīng)激反應(yīng)中高度表達(dá)，能夠攔截與內(nèi)質(zhì)網(wǎng)應(yīng)激相關(guān)的凋亡性細(xì)胞死亡。PDIA3在生物學(xué)上的意義非常廣泛，其表達(dá)在約70%的癌癥中升高，并且與腫瘤細(xì)胞的低侵襲性、存活和轉(zhuǎn)移能力有關(guān)。PDIA3還與免疫激活標(biāo)志物、癌癥免疫細(xì)胞浸潤和免疫調(diào)節(jié)劑顯著相關(guān)，特別是能夠顯著預(yù)測抗PDL1治療反應(yīng)。此外，PDIA3在T細(xì)胞受體(TCR)信號(hào)通路中具有調(diào)控作用，能夠促進(jìn)T細(xì)胞的活化，參與調(diào)節(jié)T細(xì)胞TCR信號(hào)通路，影響ZAP70蛋白的磷酸化水平、CD69表達(dá)和IL-2的分泌，以及NF-κB信號(hào)通路。因此，PDIA3不僅在蛋白質(zhì)合成、降解和分泌中發(fā)揮作用，塑造腫瘤微環(huán)境，還是癌癥預(yù)后和免疫治療反應(yīng)的有力生物標(biāo)志物，具有作為抗癌治療靶點(diǎn)的潛力。
熱銷產(chǎn)品
Recombinant Human Protein disulfide-isomerase A3 (PDIA3) (CSB-EP017720HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western Blot analysis of A549 HT29 K562 cells using ERp57 Polyclonal Antibody
Human protein disulfide-isomerase A3,PDIA3 ELISA Kit (CSB-E09798h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E09798h
規(guī)格：96T/48T
靈敏度：0.31 ng/mL
檢測范圍：1.25 ng/mL-80 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
PDIA3 Antibodies
PDIA3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06284A0Rb | PDIA3 Antibody | Human | ELISA |
| CSB-PA017720GA01HU | PDIA3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA005150 | PDIA3 Antibody | Human,Mouse,Rat | WB, ELISA |
PDIA3 Proteins
PDIA3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017720RA CSB-EP017720RA CSB-BP017720RA CSB-MP017720RA CSB-EP017720RA-B |
Recombinant Rat Protein disulfide-isomerase A3 (Pdia3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017720MO CSB-EP017720MO CSB-BP017720MO CSB-MP017720MO CSB-EP017720MO-B |
Recombinant Mouse Protein disulfide-isomerase A3 (Pdia3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017720HU CSB-BP017720HU CSB-MP017720HU CSB-EP017720HU-B |
Recombinant Human Protein disulfide-isomerase A3 (PDIA3) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017720HU | Recombinant Human Protein disulfide-isomerase A3 (PDIA3) | E.coli |
PDIA3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017720BO CSB-EP017720BO CSB-BP017720BO CSB-MP017720BO CSB-EP017720BO-B |
Recombinant Bovine Protein disulfide-isomerase A3 (PDIA3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 Proteins for Papio hamadryas (Hamadryas baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017720ERJ CSB-EP017720ERJ CSB-BP017720ERJ CSB-MP017720ERJ CSB-EP017720ERJ-B |
Recombinant Papio hamadryas Protein disulfide-isomerase A3 (PDIA3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017720MRG CSB-EP017720MRG CSB-BP017720MRG CSB-MP017720MRG CSB-EP017720MRG-B |
Recombinant Mesocricetus auratus Protein disulfide-isomerase A3 (PDIA3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP684159DSU CSB-EP684159DSU CSB-BP684159DSU CSB-MP684159DSU CSB-EP684159DSU-B |
Recombinant Chlorocebus aethiops Protein disulfide-isomerase A3 (PDIA3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP712990PYX CSB-EP712990PYX CSB-BP712990PYX CSB-MP712990PYX CSB-EP712990PYX-B |
Recombinant Pongo abelii Protein disulfide-isomerase A3 (PDIA3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP810332CH CSB-EP810332CH CSB-BP810332CH CSB-MP810332CH CSB-EP810332CH-B |
Recombinant Chicken Protein disulfide-isomerase A3 (PDIA3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDIA3 ELISA Kit
PDIA3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09798h | Human protein disulfide-isomerase A3,PDIA3 ELISA Kit | serum, plasma, cell culture supernates | 0.31 ng/mL |
