NUMBL
Numb-like protein is a protein in humans that is encoded by NUMBL gene. Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
NUMBL Antibodies
NUMBL for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA897595LA01HU | NUMBL Antibody | Human | ELISA, IHC, IF |
| CSB-PA897595LB01HU | NUMBL Antibody, HRP conjugated | Human | ELISA |
| CSB-PA897595LD01HU | NUMBL Antibody, Biotin conjugated | Human | ELISA |
NUMBL Proteins
NUMBL Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP016187RA CSB-EP016187RA CSB-BP016187RA CSB-MP016187RA CSB-EP016187RA-B |
Recombinant Rat Numb-like protein (Numbl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NUMBL Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP016187MO CSB-EP016187MO CSB-BP016187MO CSB-MP016187MO CSB-EP016187MO-B |
Recombinant Mouse Numb-like protein (Numbl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NUMBL Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP897595HU CSB-EP897595HU CSB-BP897595HU CSB-MP897595HU CSB-EP897595HU-B |
Recombinant Human Numb-like protein (NUMBL) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
