NTRK1
NTRK1，即神經(jīng)營養(yǎng)因子受體酪氨酸激酶1，別名包括TRKA、Neurotrophic Tyrosine Kinase Receptor Type 1等。它是一種膜結合受體，由NTRK1基因編碼，主要在神經(jīng)系統(tǒng)中發(fā)揮作用，參與調(diào)節(jié)細胞的增殖、分化和存活。NTRK1的作用機制是通過與神經(jīng)營養(yǎng)因子結合，激活其內(nèi)在的酪氨酸激酶活性，從而引發(fā)細胞內(nèi)信號傳導，影響細胞的存活和分化。NTRK1的信號通路包括MAPK和PI3K/AKT信號通路，這些信號通路對腫瘤細胞的增殖和存活具有重要作用。NTRK1的生物學意義主要體現(xiàn)在其對神經(jīng)系統(tǒng)發(fā)育和功能維持中的作用。NTRK1基因融合陽性腫瘤產(chǎn)生的原因是NTRK1/2/3基因與其他基因融合，導致編碼的TRK蛋白出現(xiàn)異常。變異的TRK或TRK融合蛋白持續(xù)激活，從而引發(fā)永久的信號級聯(lián)反應，這些蛋白在TRK融合癌患者中是驅(qū)動腫瘤增長和轉(zhuǎn)移的主要因素。NTRK1基因融合可能出現(xiàn)在起源于身體不同位置的腫瘤中，這使得它成為了研究人員開發(fā)“不限癌種”療法的靶標之一。
熱銷產(chǎn)品
NTRK1 Recombinant Monoclonal Antibody (CSB-RA202683A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: TrkA Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 88, 87, 84, 78 kDa
Observed band size: 145 kDa
NTRK1 Antibodies
NTRK1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA198739 | Phospho-NTRK1 (Ser791) Antibody | Human | ELISA,WB,IF |
| CSB-PA217013 | NTRK1 (Ab-791) Antibody | Human | ELISA,IF |
| CSB-PA095633 | Phospho-NTRK1 (Tyr680/681) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA078103 | Phospho-NTRK1 (Tyr791) Antibody | Human | ELISA,IHC |
| CSB-PA271642 | Phospho-NTRK1 (Tyr757) Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA830815 | Phospho-NTRK1 (Tyr701) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA020162 | Phospho-NTRK1 (Y680/Y681) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA020164 | Phospho-NTRK1 (Y701) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020165 | Phospho-NTRK1 (Y791) Antibody | Human | IHC, ELISA |
| CSB-PA020166 | Phospho-NTRK1 (Y757) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA020167 | Phospho-NTRK1 (Y496) Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA020168 | NTRK1 Antibody | Human | IHC, IF, ELISA |
| CSB-PA020169 | NTRK1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020170 | NTRK1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA979780 | NTRK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA140509 | NTRK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA016133LA01HU | NTRK1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| CSB-PA016133LB01HU | NTRK1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA016133LC01HU | NTRK1 Antibody, FITC conjugated | Human | |
| CSB-PA016133LD01HU | NTRK1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA202683A0HU | NTRK1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
NTRK1 Proteins
NTRK1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016133RA1 CSB-EP016133RA1 CSB-BP016133RA1 CSB-MP016133RA1 CSB-EP016133RA1-B |
Recombinant Rat High affinity nerve growth factor receptor (Ntrk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016133RA | Recombinant Rat High affinity nerve growth factor receptor (Ntrk1) | in vitro E.coli expression system |
NTRK1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016133HU1 CSB-EP016133HU1 CSB-BP016133HU1 CSB-MP016133HU1 CSB-EP016133HU1-B |
Recombinant Human High affinity nerve growth factor receptor (NTRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016133HU | Recombinant Human High affinity nerve growth factor receptor (NTRK1) | in vitro E.coli expression system |
NTRK1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP667566MO CSB-EP667566MO CSB-BP667566MO CSB-MP667566MO CSB-EP667566MO-B |
Recombinant Mouse High affinity nerve growth factor receptor (Ntrk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP835489CH CSB-EP835489CH CSB-BP835489CH CSB-MP835489CH CSB-EP835489CH-B |
Recombinant Chicken High affinity nerve growth factor receptor (NTRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
