NHLRC1
E3 ubiquitin-protein ligase NHLRC1 is a protein in humans that is encoded by NHLRC1 gene. E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
NHLRC1 Antibodies
NHLRC1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015790GA01HU | NHLRC1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA740936ESR1HU | NHLRC1 Antibody | Human, Rat | ELISA, WB |
| CSB-PA740936ESR2HU | NHLRC1 Antibody | Human, Rat | ELISA, WB, IHC,IF |
| CSB-PA740936LA01HU | NHLRC1 Antibody | Human | ELISA, IHC |
| CSB-PA740936LD01HU | NHLRC1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA740936LC01HU | NHLRC1 Antibody, FITC conjugated | Human |
NHLRC1 Proteins
NHLRC1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP740936HU CSB-EP740936HU CSB-BP740936HU CSB-MP740936HU CSB-EP740936HU-B |
Recombinant Human E3 ubiquitin-protein ligase NHLRC1 (NHLRC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NHLRC1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP757096RA CSB-EP757096RA CSB-BP757096RA CSB-MP757096RA CSB-EP757096RA-B |
Recombinant Rat E3 ubiquitin-protein ligase NHLRC1 (Nhlrc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NHLRC1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP807395MO CSB-EP807395MO CSB-BP807395MO CSB-MP807395MO CSB-EP807395MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase NHLRC1 (Nhlrc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
