MYD88
MYD88，即髓樣分化因子88。它是一種在造血干細胞和淋巴組織中表達的轉錄因子，廣泛參與免疫信號的傳遞。MYD88的來源是人體自身的基因編碼，它作為細胞內傳遞信號的關鍵銜接蛋白，主要介導多種Toll樣受體（TLR）、白細胞介素1受體（IL-1R）及白細胞介素-18受體（IL-18R）的信號傳遞，在固有免疫中發(fā)揮顯著作用。MYD88的作用機制涉及到它與各種受體的相互作用，通過其TIR結構域（Toll-白細胞介素1受體域）識別受體激活后的信號，進而招募并激活下游的信號分子，如IRAK（白細胞介素-1受體相關激酶）等。這導致核因子-κB（NF-κB）和MAPK（絲裂原活化蛋白激酶）等轉錄因子的激活，從而調節(jié)炎癥因子的表達。MYD88的信號通路包括但不限于NF-κB通路、JAK-STAT3（酪氨酸激酶-信號轉導子和轉錄激活子3）信號通路等，這些通路在細胞增殖、分化以及炎癥反應中扮演關鍵角色。MYD88的生物學意義主要體現(xiàn)在其對固有免疫應答的調控上。它不僅參與病原體識別和炎癥反應的啟動，還與腫瘤、感染性疾病、自身免疫性疾病等的發(fā)病機制密切相關。MYD88依賴的信號通路被認為是這些疾病治療的潛在靶點。特別是，MYD88基因的某些突變，如L265P，可以導致炎癥因子產生增加，這在淋巴漿細胞淋巴瘤等疾病中尤為重要。因此，對MYD88的研究不僅有助于我們理解免疫應答的復雜性，也為開發(fā)新的治療策略提供了可能。
熱銷產品
Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) (CSB-EP859945HU)
驗證數(shù)據(jù)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP859945HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MYD88.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP859945HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MYD88.
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MYD88 Antibody (CSB-PA859945LA01HU)
驗證數(shù)據(jù)
Immunofluorescent analysis of HepG2 cells using CSB-PA859945LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human myeloid differentiation factor 88, MyD88 ELISA Kit (CSB-E11747h)
驗證數(shù)據(jù)
貨號：CSB-E11747h
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312ng/mL-20ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MYD88 Antibodies
MYD88 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA003338 | MYD88 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA995911 | MYD88 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA859945LA01HU | MYD88 Antibody | Human | ELISA, IF |
| CSB-PA859945LB01HU | MYD88 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA859945LC01HU | MYD88 Antibody, FITC conjugated | Human | |
| CSB-PA859945LD01HU | MYD88 Antibody, Biotin conjugated | Human | ELISA |
MYD88 Proteins
MYD88 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282MO CSB-EP015282MO CSB-BP015282MO CSB-MP015282MO CSB-EP015282MO-B |
Recombinant Mouse Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282PI CSB-EP015282PI CSB-BP015282PI CSB-MP015282PI CSB-EP015282PI-B |
Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282CH CSB-EP015282CH CSB-BP015282CH CSB-MP015282CH CSB-EP015282CH-B |
Recombinant Chicken Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282MOW CSB-EP015282MOW CSB-BP015282MOW CSB-MP015282MOW CSB-EP015282MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282SH CSB-EP015282SH CSB-BP015282SH CSB-MP015282SH CSB-EP015282SH-B |
Recombinant Sheep Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282TKY CSB-EP015282TKY CSB-BP015282TKY CSB-MP015282TKY CSB-EP015282TKY-B |
Recombinant Takifugu rubripes Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Salmo salar (Atlantic salmon)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282SWI CSB-EP015282SWI CSB-BP015282SWI CSB-MP015282SWI CSB-EP015282SWI-B |
Recombinant Salmo salar Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282MOV CSB-EP015282MOV CSB-BP015282MOV CSB-MP015282MOV CSB-EP015282MOV-B |
Recombinant Macaca fascicularis Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282GGZ CSB-EP015282GGZ CSB-BP015282GGZ CSB-MP015282GGZ CSB-EP015282GGZ-B |
Recombinant Gorilla gorilla gorilla Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282EQV CSB-EP015282EQV CSB-BP015282EQV CSB-MP015282EQV CSB-EP015282EQV-B |
Recombinant Pan troglodytes Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282EQU CSB-EP015282EQU CSB-BP015282EQU CSB-MP015282EQU CSB-EP015282EQU-B |
Recombinant Pan paniscus Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282EXP CSB-EP015282EXP CSB-BP015282EXP CSB-MP015282EXP CSB-EP015282EXP-B |
Recombinant Pongo pygmaeus Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015282DRI CSB-EP015282DRI CSB-BP015282DRI CSB-MP015282DRI CSB-EP015282DRI-B |
Recombinant Cercocebus atys Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP635725XBF CSB-EP635725XBF CSB-BP635725XBF CSB-MP635725XBF CSB-EP635725XBF-B |
Recombinant Xenopus tropicalis Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP685436BO CSB-EP685436BO CSB-BP685436BO CSB-MP685436BO CSB-EP685436BO-B |
Recombinant Bovine Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP708955OEI CSB-EP708955OEI CSB-BP708955OEI CSB-MP708955OEI CSB-EP708955OEI-B |
Recombinant Oncorhynchus mykiss Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP730396DIL CSB-EP730396DIL CSB-BP730396DIL CSB-MP730396DIL CSB-EP730396DIL-B |
Recombinant Danio rerio Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP744333RA CSB-EP744333RA CSB-BP744333RA CSB-MP744333RA CSB-EP744333RA-B |
Recombinant Rat Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP859945HU CSB-BP859945HU CSB-MP859945HU CSB-EP859945HU-B |
Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP859945HU | Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) | E.coli |
MYD88 ELISA Kit
MYD88 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11747h | Human myeloid differentiation factor 88, MyD88 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
MYD88 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12109m | Mouse myeloid differentiation factor 88, MyD88 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 11.7 pg/mL |
