MPL
MPL，即巨核細(xì)胞增生性白血病病毒受體，別名Myeloproliferative Leukemia Virus Receptor、CD110等。MPL是一種表達(dá)于造血干細(xì)胞、早期髓系和淋巴系前體細(xì)胞、內(nèi)皮細(xì)胞以及某些腫瘤細(xì)胞表面的細(xì)胞表面受體。它屬于腫瘤壞死因子受體超家族成員，由人體細(xì)胞自身的基因編碼。MPL的作用機(jī)制主要涉及與多種配體結(jié)合，如TPO（血小板生成素）、ELN（內(nèi)皮細(xì)胞白血病抑制因子）等，這些配體的結(jié)合能夠激活MPL，進(jìn)而觸發(fā)下游的JAK2/STAT、MAPK等信號(hào)通路，促進(jìn)巨核細(xì)胞的增殖和分化，影響血小板的生成。MPL在正常的造血過(guò)程中發(fā)揮著關(guān)鍵作用，尤其是在血小板的生成和功能的維持中。MPL的激活可以促進(jìn)巨核細(xì)胞的增殖和成熟，從而增加血小板的產(chǎn)生。此外，MPL還參與了對(duì)炎癥反應(yīng)、血管生成和免疫調(diào)節(jié)等過(guò)程的調(diào)控。MPL的功能異常與某些骨髓增生性疾病的發(fā)生發(fā)展有關(guān)，如原發(fā)性血小板增多癥、骨髓增生異常綜合征等。因此，MPL是血液學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Thrombopoietin receptor (MPL), partial (CSB-EP014755HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MPL Antibody (CSB-PA014755LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA014755LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA014755LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA014755LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MPL Antibodies
MPL for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005848 | MPL Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010219 | MPL Antibody | Human | WB, ELISA |
| CSB-PA014755LA01HU | MPL Antibody | Human | ELISA, IHC, IF |
| CSB-PA014755LB01HU | MPL Antibody, HRP conjugated | Human | ELISA |
| CSB-PA014755LC01HU | MPL Antibody, FITC conjugated | Human |
MPL Proteins
MPL Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP014755HU | Recombinant Human Thrombopoietin receptor (MPL), partial | Yeast |
| CSB-EP014755HU | Recombinant Human Thrombopoietin receptor (MPL), partial | E.coli |
| CSB-BP014755HU CSB-MP014755HU CSB-EP014755HU-B |
Recombinant Human Thrombopoietin receptor (MPL), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP332898LPY CSB-EP332898LPY CSB-BP332898LPY CSB-MP332898LPY CSB-EP332898LPY-B |
Recombinant Listeria monocytogenes serovar 1/2a Zinc metalloproteinase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Listeria monocytogenes
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP333848LGW CSB-EP333848LGW CSB-BP333848LGW CSB-MP333848LGW CSB-EP333848LGW-B |
Recombinant Zinc metalloproteinase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP337588HTA CSB-EP337588HTA CSB-BP337588HTA CSB-MP337588HTA CSB-EP337588HTA-B |
Recombinant Haemophilus influenzae UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Escherichia coli (strain K12)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP339870ENV CSB-EP339870ENV CSB-BP339870ENV CSB-MP339870ENV CSB-EP339870ENV-B |
Recombinant Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP600093MO CSB-EP600093MO CSB-BP600093MO CSB-MP600093MO CSB-EP600093MO-B |
Recombinant Mouse Thrombopoietin receptor (Mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
