LILRB1
LILRB1，即白細(xì)胞免疫球蛋白樣受體B1，別名ILT2（免疫球蛋白樣轉(zhuǎn)錄物2）、LIR1（白細(xì)胞免疫受體1）、CD85j。LILRB1是一種主要在髓系細(xì)胞上表達(dá)的抑制性受體，它通過(guò)與MHC I類分子等配體結(jié)合來(lái)調(diào)節(jié)免疫細(xì)胞的活性。LILRB1的作用機(jī)制涉及到其胞內(nèi)結(jié)構(gòu)域中的免疫受體酪氨酸抑制基序（ITIM），當(dāng)LILRB1與其配體結(jié)合時(shí)，可以招募含有磷酸酶SHP-1（Src同源區(qū)域2結(jié)構(gòu)域含有的磷酸酶1）的分子，從而抑制過(guò)度的免疫反應(yīng)和促進(jìn)免疫耐受。LILRB1在生物學(xué)上的意義主要體現(xiàn)在其對(duì)免疫應(yīng)答的調(diào)節(jié)作用。它在樹(shù)突狀細(xì)胞的分化和功能中發(fā)揮關(guān)鍵作用，能夠影響樹(shù)突狀細(xì)胞分泌細(xì)胞因子的能力，如IL-10、IL-12p70和TGF-β，進(jìn)而調(diào)節(jié)T細(xì)胞的激活和增殖。此外，LILRB1還在腫瘤免疫微環(huán)境中起到重要作用，其表達(dá)在腫瘤相關(guān)巨噬細(xì)胞（TAM）上被上調(diào)，通過(guò)與腫瘤細(xì)胞表面的MHC I類分子結(jié)合，可能幫助腫瘤細(xì)胞逃避免疫系統(tǒng)的攻擊。因此，LILRB1不僅在維持免疫平衡中發(fā)揮重要作用，也是癌癥免疫治療中的潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human LIR-1 (LILRB1), partial, Biotinylated (CSB-MP5114HU-B)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of LILRB1 was greater than 90% as determined by SEC-HPLC
LILRB1 Antibody (CSB-PA847747LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: THP-1 whole cell lysate, Rat brain tissue
All lanes: LILRB1 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 71, 72, 50 kDa
Observed band size: 71 kDa
IHC image of CSB-PA847747LA01HU diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of 293 cells with CSB-PA847747LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
LILRB1 Antibodies
LILRB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006214 | LILRB1 Antibody | Human | WB, ELISA |
| CSB-PA184311 | LILRB1 Antibody | Human | ELISA,IHC |
| CSB-PA152513 | LILRB1 Antibody | Human | ELISA,IHC |
| CSB-PA847747LA01HU | LILRB1 Antibody | Human, Rat | ELISA, WB, IHC, IF |
| CSB-PA847747LB01HU | LILRB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA847747LC01HU | LILRB1 Antibody, FITC conjugated | Human | |
| CSB-PA847747LD01HU | LILRB1 Antibody, Biotin conjugated | Human | ELISA |
LILRB1 Proteins
LILRB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP847747HU CSB-EP847747HU CSB-BP847747HU CSB-EP847747HU-B |
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
