KNG1
激肽原（Kininogen-1，簡(jiǎn)稱KNG1）是人體血漿中重要的多功能糖蛋白，其高分子量形式（HMWK）和低分子量形式（LMWK）分別參與不同生理過程。該蛋白在傳統(tǒng)研究中被稱為Fitzgerald因子或接觸激活輔因子，是激肽系統(tǒng)核心成員之一。其通過釋放緩激肽等活性肽段，協(xié)調(diào)血管張力調(diào)節(jié)、凝血平衡和炎癥反應(yīng)，尤其在血管內(nèi)皮保護(hù)與損傷修復(fù)中具有雙向調(diào)節(jié)特性。
激肽原水平異常與遺傳性血管水腫、血栓性疾病及高血壓密切相關(guān)。在動(dòng)脈粥樣硬化進(jìn)程中，該蛋白既能通過抗凝作用抑制血栓形成，又會(huì)因過度激活補(bǔ)體系統(tǒng)加重炎癥反應(yīng)，這種矛盾特性使其成為治療靶點(diǎn)研究的焦點(diǎn)。目前針對(duì)緩激肽受體的抑制劑（如艾替班特）已用于遺傳性血管水腫急性發(fā)作治療，而基于激肽原結(jié)構(gòu)設(shè)計(jì)的抗血栓藥物正處于臨床前研究階段。近期有學(xué)者探索其修飾產(chǎn)物在腫瘤微環(huán)境調(diào)控中的應(yīng)用，為癌癥治療提供了新思路。
熱銷產(chǎn)品
Recombinant Human Kininogen-1 (KNG1), partial (CSB-EP012479HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KNG1 Antibody (CSB-PA14647A0Rb)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: KNG1 antibody at 2µg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 72, 48, 44 kDa
Observed band size: 72 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA14647A0Rb at dilution of 1:50
Immunofluorescent analysis of HepG2 cells using CSB-PA14647A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Kininogen-1(KNG1) ELISA kit (CSB-EL012479HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL012479HU
規(guī)格：96T/48T
靈敏度：11.75 ng/mL
檢測(cè)范圍：47 ng/mL-3000 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
KNG1 Antibodies
KNG1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA14647B0Rb | KNG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA14647D0Rb | KNG1 Antibody, Biotin conjugated | Human | ELISA, IHC |
| CSB-PA012479GA01HU | KNG1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA14647A0Rb | KNG1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA009655 | Cleaved-KNG1 (K380) Antibody | Human | WB, ELISA |
KNG1 for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012479LA01RA | Kng1 Antibody | Rat | ELISA |
KNG1 Proteins
KNG1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012479HU CSB-EP012479HU CSB-BP012479HU CSB-MP012479HU CSB-EP012479HU-B |
Recombinant Human Kininogen-1 (KNG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012479HU | Recombinant Human Kininogen-1 (KNG1), partial | E.coli |
KNG1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012479BO CSB-EP012479BO CSB-BP012479BO CSB-MP012479BO CSB-EP012479BO-B |
Recombinant Bovine Kininogen-1 (KNG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012479RA | Recombinant Rat Kininogen-1 (Kng1), partial | Yeast |
| CSB-EP012479RA CSB-BP012479RA CSB-MP012479RA CSB-EP012479RA-B |
Recombinant Rat Kininogen-1 (Kng1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012479MO CSB-EP012479MO CSB-BP012479MO CSB-MP012479MO CSB-EP012479MO-B |
Recombinant Mouse Kininogen-1 (Kng1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 ELISA Kit
KNG1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012479HU | Human Kininogen-1(KNG1) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 11.75 ng/mL |
KNG1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12725r | Rat kininogen(KNG) ELISA Kit | serum, plasma, tissue homogenates | 0.097 ng/ml |
