IL18
IL18，即白介素18，它是一種在人體中由IL18基因編碼的細胞因子，屬于IL-1家族成員。IL18在多種細胞類型中表達，包括T細胞、NK細胞、樹突狀細胞等。其作用機制涉及到與IL18受體結合，該受體由α鏈和β鏈組成，其中α鏈負責配體結合，β鏈介導信號傳導。IL18通過與其受體結合，激活下游的信號傳導途徑，如通過JAK/STAT通路，進而影響細胞的增殖、分化和效應功能。IL18在生物學上的意義主要體現在其作為免疫調節因子參與炎癥和免疫應答過程。它能誘導T細胞產生干擾素-γ（IFN-γ），促進NK細胞和其他免疫細胞的活化，以及刺激細胞因子如腫瘤壞死因子-α（TNF-α）、IL-1β等的產生。IL18在促進Th1型免疫應答中發揮重要作用，并與多種炎癥性疾病、腫瘤和自身免疫性疾病的發生發展密切相關。例如，IL18的表達水平在某些自身免疫疾病中升高，可能作為疾病活動性的標志。此外，IL18的成熟過程涉及非經典炎癥小體途徑，其中caspase-4/5的活化可以切割前體IL18，釋放其成熟形式以發揮生物學功能。
熱銷產品
Recombinant Human Interleukin-18 (IL18) (CSB-EP614514HUd7)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL18 Antibody (CSB-PA614514YA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA614514YA01HU at dilution of 1:20
Human Interleukin 18,IL-18 ELISA KIT (CSB-E07450h)
驗證數據
貨號：CSB-E07450h
規格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL18 Antibodies
IL18 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011608GA01HU | IL18 Antibody | Human, Rat | ELISA,WB,IHC,IF |
| CSB-PA614514YA01HU | IL18 Antibody | Human | ELISA, IHC |
| CSB-PA614514YD01HU | IL18 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA614514YC01HU | IL18 Antibody, FITC conjugated | Human | |
| CSB-PA614514YB01HU | IL18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08377A0Rb | IL18 Antibody | Human | ELISA |
| CSB-PA08377B0Rb | IL18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08377C0Rb | IL18 Antibody, FITC conjugated | Human | |
| CSB-PA08377D0Rb | IL18 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA081015 | IL18 Antibody | Human | ELISA,WB,IHC |
| CSB-PA634259 | IL18 Antibody | Human | ELISA,WB,IHC |
| CSB-RA614514MA1HU | IL18 Recombinant Monoclonal Antibody | Human | ELISA, FC |
IL18 for Dog
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA895937LA01DO | IL18 Antibody | Dog | ELISA |
IL18 Proteins
IL18 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011608MO | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-EP011608MO | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
| CSB-BP011608MO CSB-MP011608MO CSB-EP011608MO-B |
Recombinant Mouse Interleukin-18 (Il18) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-YP011608MOb0 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-EP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
IL18 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011608RA CSB-EP011608RA CSB-BP011608RA CSB-MP011608RA CSB-EP011608RA-B |
Recombinant Rat Interleukin-18 (Il18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP176194r | Recombinant Rat Interleukin-18 (Il18) | E.coli |
IL18 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011608PI CSB-EP011608PI CSB-BP011608PI CSB-MP011608PI CSB-EP011608PI-B |
Recombinant Pig Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP614514HU | Recombinant Human Interleukin-18 (IL18) | Yeast |
| CSB-EP614514HU CSB-BP614514HU CSB-MP614514HU CSB-EP614514HU-B |
Recombinant Human Interleukin-18 (IL18) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | Yeast |
| CSB-EP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-EP614514HUd7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-EP614514HUc7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-MP614514HU-WD | Recombinant Human Interleukin-18 (IL18) (Active) | Mammalian cell |
IL18 Proteins for Capra hircus (Goat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP672507GO CSB-EP672507GO CSB-BP672507GO CSB-MP672507GO CSB-EP672507GO-B |
Recombinant Goat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Boselaphus tragocamelus (Nilgai)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP689269BUN CSB-EP689269BUN CSB-BP689269BUN CSB-MP689269BUN CSB-EP689269BUN-B |
Recombinant Boselaphus tragocamelus Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP819130CH CSB-EP819130CH CSB-BP819130CH CSB-MP819130CH CSB-EP819130CH-B |
Recombinant Chicken Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP850184CA CSB-EP850184CA CSB-BP850184CA CSB-MP850184CA CSB-EP850184CA-B |
Recombinant Cat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP866143BO CSB-EP866143BO CSB-BP866143BO CSB-MP866143BO CSB-EP866143BO-B |
Recombinant Bovine Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Equus caballus (Horse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP895012HO CSB-EP895012HO CSB-BP895012HO CSB-MP895012HO CSB-EP895012HO-B |
Recombinant Horse Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP895937DO CSB-BP895937DO CSB-MP895937DO CSB-EP895937DO-B |
Recombinant Dog Interleukin-18 (IL18) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP895937DO | Recombinant Dog Interleukin-18 (IL18) | E.coli |
IL18 ELISA Kit
IL18 ELISA Kit for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011608BO | Bovine Interleukin-18(IL18) ELISA kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10070Ch | Chicken Interleukin 18,IL-18 ELISA KIT | serum, plasma, tissue Homogenates | 1.95 pg/mL |
IL18 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09848c | Dog Interleukin 18,IL-18 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 3.12 pg/mL |
IL18 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07450h | Human Interleukin 18,IL-18 ELISA KIT | serum, plasma, urine, tissue homogenates | 7.8 pg/mL |
IL18 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04609m | Mouse Interleukin 18,IL-18 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.39 pg/mL |
IL18 ELISA Kit for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E06781p | Pig Interleukin 18,IL-18 ELISA Kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04610r | Rat Interleukin 18,IL-18 Elisa Kit | serum, plasma, cell culture supernates | 0.039 ng/mL |
