IGF1R

IGF1R，全稱胰島素樣生長因子1受體蛋白，是一種細胞表面受體，參與生長調節和發育。它也被稱為IGFIR、IGFR、JTK13、CD221、MGC142170、MGC142172、MGC18216等。IGF1R蛋白的失調與癌癥和生長障礙等疾病有關。靶向IGF1R蛋白可能通過調節細胞生長、抑制腫瘤進展和管理生長相關疾病，為這些疾病提供潛在的治療干預。
IGF1R蛋白在多種信號通路中發揮重要作用，包括PI3K-AKT/PKB、Ras-MAPK、JAK/STAT和JNK通路。這些通路涉及細胞的生長、存活、增殖和轉化。IGF1R蛋白的高表達與多種癌癥的發生發展有關，如非小細胞肺癌、乳腺癌、結直腸癌等。此外，IGF1R蛋白也與一些其他疾病有關，如2型糖尿病、骨質疏松等。
目前，針對IGF1R蛋白的藥物研發主要集中在抗體類藥物和小分子抑制劑。抗體類藥物可以通過結合IGF1R蛋白，阻斷其信號通路，從而抑制腫瘤細胞的增殖和轉移。小分子抑制劑可以抑制IGF1R蛋白的激酶活性，從而抑制腫瘤細胞的生長和增殖。目前，已有多種IGF1R靶向藥物進入臨床試驗階段，部分藥物已獲得批準上市，為癌癥患者提供了新的治療選擇。

熱銷產品

Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (Active) (CSB-MP011087HU1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IGF1R at 2 μg/ml can bind Anti-IGF1R recombinant antibody (CSB-RA011087MA2HU). The EC₅₀ is 1.479-1.702 ng/mL.

The purity of IGF1R was greater than 90% as determined by SEC-HPLC

IGF1R Recombinant Monoclonal Antibody (CSB-RA011087MA2HU)

驗證數據

The Binding Activity of Human IGF1R with Anti-IGF1R Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGF1R (CSB-MP011087HU1) at 2 μg/mL can bind Anti-IGF1R recombinant antibody. The EC₅₀ is 1.479-1.702 ng/mL.

IHC image of CSB-RA011087MA2HU diluted at 1:50 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA011087MA2HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of MCF-7 cell with CSB-RA011087MA2HU at 1:30 ,counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific.

Immunofluorescence staining of SH-SY5Y cell with CSB-RA011087MA2HU at 1:30 ,counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific.

Overlay Peak curve showing Hela cells stained with CSB-RA011087MA2HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35 min at 4℃.Control antibody (green line) was mouse IgG2a (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human insulin-like growth factors 1 receptor,IGF-1R ELISA Kit (CSB-E13766h)

驗證數據

貨號：CSB-E13766h

規格：96T/48T

靈敏度：0.078 ng/mL

檢測范圍：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IGF1R Antibody

IGF1R Protein

IGF1R ELISA Kit

IGF1R Antibodies

IGF1R for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA011087GA01HU	IGF1R Antibody	Human,Mouse,Rat	ELISA,WB,IP
CSB-PA597654	Phospho-IGF1R (Tyr1165/Tyr1166) Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA067618	IGF1R (Ab-1161) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA142373	IGF1R (Ab-1165/1166) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA443662	IGF1R (Ab-1280) Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA449888	Phospho-IGF1R (Tyr1280) Antibody	Human	ELISA,WB
CSB-PA277594	IGF1R (Ab-1346) Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA120059	Phospho-IGF1R (Tyr1161) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA945418	Phospho-IGF1R (Tyr1346) Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA942675	IGF1R (Ab-1346) Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA000549	Phospho-IGF1R (Y1165/Y1166) Antibody	Human,Mouse,Rat,Monkey	WB, ELISA
CSB-PA009487	Phospho-IGF1R (Y1346) Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA009488	IGF1R Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA009489	IGF1R Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA009490	IGF1R Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA08395A0Rb	IGF1R Antibody	Human	ELISA, IF
CSB-PA08395B0Rb	IGF1R Antibody, HRP conjugated	Human	ELISA
CSB-PA08395D0Rb	IGF1R Antibody, Biotin conjugated	Human	ELISA
CSB-RA011087MA1HU	IGF1R Recombinant Monoclonal Antibody	Human	ELISA, FC
CSB-RA011087MA2HU	IGF1R Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF, FC

IGF1R Proteins

IGF1R Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP011087RA1 CSB-EP011087RA1 CSB-BP011087RA1 CSB-MP011087RA1 CSB-EP011087RA1-B	Recombinant Rat Insulin-like growth factor 1 receptor (Igf1r), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011087RA	Recombinant Rat Insulin-like growth factor 1 receptor (Igf1r)	in vitro E.coli expression system

IGF1R Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP011087HU	Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial	Yeast
CSB-EP011087HUa0	Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial	E.coli
CSB-EP011087HU	Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial	E.coli
CSB-BP011087HU	Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial	Baculovirus
CSB-EP011087HU-B	Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial,Biotinylated	E.coli
CSB-MP011087HU1	Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (Active)	Mammalian cell

IGF1R Proteins for Xenopus laevis (African clawed frog)

產品貨號	產品名稱	來源
CSB-YP011087XBE1 CSB-EP011087XBE1 CSB-BP011087XBE1 CSB-MP011087XBE1 CSB-EP011087XBE1-B	Recombinant Xenopus laevis Insulin-like growth factor 1 receptor (igf1r), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011087XBE	Recombinant Xenopus laevis Insulin-like growth factor 1 receptor (igf1r)	in vitro E.coli expression system

IGF1R Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP011087MO CSB-EP011087MO CSB-BP011087MO CSB-MP011087MO CSB-EP011087MO-B	Recombinant Mouse Insulin-like growth factor 1 receptor (Igf1r), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IGF1R Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP011087PI CSB-EP011087PI CSB-BP011087PI CSB-MP011087PI CSB-EP011087PI-B	Recombinant Pig Insulin-like growth factor 1 receptor (IGF1R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli