IDUA
IDUA（Iduronidase）是一種屬于糖苷水解酶家族的溶酶體酶，其結(jié)構(gòu)復(fù)雜，包含多個催化位點和底物結(jié)合位點，能夠識別和分解硫酸艾杜糖醛酸，這是黏多糖代謝中的關(guān)鍵步驟。IDUA的主要功能是催化硫酸艾杜糖醛酸的水解，維持細(xì)胞外基質(zhì)的穩(wěn)態(tài)和正常生理功能。盡管IDUA不直接參與信號轉(zhuǎn)導(dǎo)，但它在黏多糖代謝中的作用可能間接影響某些信號通路，如通過影響細(xì)胞表面的受體與配體相互作用以及細(xì)胞間相互作用來改變細(xì)胞對外部刺激的響應(yīng)。IDUA的缺乏會導(dǎo)致黏多糖累積病，如粘多糖貯積癥I型（Hurler綜合征），這突顯了IDUA在人體健康中的重要作用。
熱銷產(chǎn)品
IDUA Antibody (CSB-PA011000LA01HU)
驗證數(shù)據(jù)
IHC image of CSB-PA011000LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA011000LA01HU diluted at 1:300 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IDUA Antibodies
IDUA for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011000GA01HU | IDUA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA011000LA01HU | IDUA Antibody | Human | ELISA, IHC |
| CSB-PA011000LB01HU | IDUA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011000LC01HU | IDUA Antibody, FITC conjugated | Human | |
| CSB-PA011000LD01HU | IDUA Antibody, Biotin conjugated | Human | ELISA |
IDUA Proteins
IDUA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011000HU | Recombinant Human Alpha-L-iduronidase (IDUA) | Yeast |
| CSB-EP011000HU | Recombinant Human Alpha-L-iduronidase (IDUA) | E.coli |
| CSB-BP011000HU CSB-MP011000HU CSB-EP011000HU-B |
Recombinant Human Alpha-L-iduronidase (IDUA) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011000HUa2 | Recombinant Human Alpha-L-iduronidase (IDUA) | E.coli |
IDUA ELISA Kit
IDUA ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09455h | Human α-L-iduronidase,IDUA ELISA Kit | serum, plasma, cell lysates, tissue homogenates | 0.039 ng/mL |
