HCST
Hematopoietic cell signal transducer is a protein in humans that is encoded by HCST gene. Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.
HCST Proteins
HCST Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010233MOV CSB-EP010233MOV CSB-BP010233MOV CSB-MP010233MOV CSB-EP010233MOV-B |
Recombinant Macaca fascicularis Hematopoietic cell signal transducer (HCST), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCST Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010233RA CSB-EP010233RA CSB-BP010233RA CSB-MP010233RA CSB-EP010233RA-B |
Recombinant Rat Hematopoietic cell signal transducer (Hcst), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCST Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010233MOW CSB-EP010233MOW CSB-BP010233MOW CSB-MP010233MOW CSB-EP010233MOW-B |
Recombinant Macaca mulatta Hematopoietic cell signal transducer (HCST), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCST Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010233HU CSB-EP010233HU CSB-BP010233HU CSB-MP010233HU CSB-EP010233HU-B |
Recombinant Human Hematopoietic cell signal transducer (HCST), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCST Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010233MO CSB-EP010233MO CSB-BP010233MO CSB-MP010233MO CSB-EP010233MO-B |
Recombinant Mouse Hematopoietic cell signal transducer (Hcst), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCST Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010233PI CSB-EP010233PI CSB-BP010233PI CSB-MP010233PI CSB-EP010233PI-B |
Recombinant Pig Hematopoietic cell signal transducer (HCST), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCST Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010233BO CSB-EP010233BO CSB-BP010233BO CSB-MP010233BO CSB-EP010233BO-B |
Recombinant Bovine Hematopoietic cell signal transducer (HCST), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
