FZD1
FZD1，全稱Frizzled class receptor 1，也被稱為FZD1/Frizzled 1蛋白，屬于G蛋白偶聯(lián)受體Fz/Smo家族。該蛋白在多種組織中表達(dá)，包括心臟、胎盤、肺、腎臟、胰腺、前列腺和卵巢，以及胎兒肺和腎臟。FZD1蛋白在細(xì)胞信號(hào)傳導(dǎo)中發(fā)揮著重要作用，參與調(diào)控細(xì)胞極性、胚胎發(fā)育、神經(jīng)突觸形成、細(xì)胞增殖等過(guò)程。FZD1蛋白是Wnt信號(hào)通路中的關(guān)鍵受體，能夠與Wnt蛋白結(jié)合，進(jìn)而激活下游信號(hào)通路。研究表明，F(xiàn)ZD1蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)，例如癌癥、心血管疾病、神經(jīng)退行性疾病等。由于FZD1蛋白在疾病中的重要作用，它已成為藥物研發(fā)的潛在靶點(diǎn)。目前，針對(duì)FZD1蛋白的藥物研發(fā)主要集中在靶向Wnt信號(hào)通路異常激活的癌癥治療。例如，研究人員正在開發(fā)針對(duì)FZD1蛋白的抑制劑，以阻斷Wnt信號(hào)通路，從而抑制腫瘤細(xì)胞的生長(zhǎng)和擴(kuò)散。此外，F(xiàn)ZD1蛋白也被用于開發(fā)針對(duì)其他疾病的藥物，例如心血管疾病和神經(jīng)退行性疾病。
熱銷產(chǎn)品
FZD1 Antibody (CSB-PA891570LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA891570LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA891570LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA891570LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
FZD1 Antibodies
FZD1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002579 | FZD1 Antibody | Human | WB, IF, ELISA |
| CSB-PA060234 | FZD1 Antibody | Human | WB, IF, ELISA |
| CSB-PA974307 | FZD1 Antibody | Human | ELISA,WB |
| CSB-PA063513 | FZD1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA991727 | FZD1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA891570LA01HU | FZD1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA891570LB01HU | FZD1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA891570LC01HU | FZD1 Antibody, FITC conjugated | Human | |
| CSB-PA891570LD01HU | FZD1 Antibody, Biotin conjugated | Human | ELISA |
FZD1 Proteins
FZD1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009103MO1 CSB-EP009103MO1 CSB-BP009103MO1 CSB-MP009103MO1 CSB-EP009103MO1-B |
Recombinant Mouse Frizzled-1 (Fzd1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009103MO | Recombinant Mouse Frizzled-1 (Fzd1) | in vitro E.coli expression system |
FZD1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009103CH1 CSB-EP009103CH1 CSB-BP009103CH1 CSB-MP009103CH1 CSB-EP009103CH1-B |
Recombinant Chicken Frizzled-1 (FZD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009103CH | Recombinant Chicken Frizzled-1 (FZD1) | in vitro E.coli expression system |
FZD1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP888253XBE1 CSB-EP888253XBE1 CSB-BP888253XBE1 CSB-MP888253XBE1 CSB-EP888253XBE1-B |
Recombinant Xenopus laevis Frizzled-1 (fzd1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF888253XBE | Recombinant Xenopus laevis Frizzled-1 (fzd1) | in vitro E.coli expression system |
FZD1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP891570HU1 CSB-EP891570HU1 CSB-BP891570HU1 CSB-MP891570HU1 CSB-EP891570HU1-B |
Recombinant Human Frizzled-1 (FZD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF891570HU | Recombinant Human Frizzled-1 (FZD1) | in vitro E.coli expression system |
