FGFR2

FGFR2，即成纖維細胞生長因子受體2，別名FGFRβ、Bek、CFD1等。FGFR2是一種跨膜受體酪氨酸激酶，由人體細胞自身的基因編碼，主要在胚胎發育、組織再生、細胞增殖和遷移等過程中發揮作用。FGFR2的作用機制涉及與多種成纖維細胞生長因子(FGF)配體結合，如FGF1、FGF2、FGF4、FGF5等，進而激活其內在的酪氨酸激酶活性，啟動下游的信號傳導途徑，如RAS/RAF/MEK/ERK、PI3K/AKT等。FGFR2在生物學上的意義非常廣泛，它參與調節多種細胞過程，包括細胞增殖、分化、遷移和存活。FGFR2的信號通路與組織發育、傷口愈合、腫瘤生長和血管生成等生理和病理過程密切相關。FGFR2的功能異常與多種疾病有關，尤其是與某些類型的癌癥相關，如乳腺癌、胃癌、非小細胞肺癌等。在腫瘤中，FGFR2的突變或過表達可能導致細胞增殖失控和腫瘤血管生成，促進腫瘤的侵襲和轉移。因此，FGFR2是腫瘤治療中的一個潛在靶點，針對FGFR2的抑制劑正在被開發用于治療相關癌癥。

熱銷產品

Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial (Active) (CSB-MP008645HU1(F3))

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA1HU). The EC₅₀ is 1.066-1.203 ng/mL.

Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2), partial (Active) (CSB-MP008645MO1(F2))

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA1HU). The EC₅₀ is 2.084-2.249 ng/mL.

Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial (Active) (CSB-MP008645HU1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA2HU). The EC₅₀ is 2.051-2.322 ng/mL.

Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial (Active) (CSB-MP008645HU(F3))

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA1HU). The EC₅₀ is 1.066-1.203 ng/mL.

The purity of FGFR2 was greater than 95% as determined by SEC-HPLC

FGFR2 Recombinant Monoclonal Antibody (CSB-RA154582A0HU)

驗證數據

Western Blot
Positive WB detected in: Rat Brain whole cell lysate, Rat Lung whole cell lysate, Mouse Brain whole cell lysate
All lanes: FGFR2 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 93, 87, 93, 77, 92, 89, 86, 29, 80, 93, 97, 92, 41, 80, 80, 77, 80 kDa
Observed band size: 145 kDa

FGFR2 Antibody

FGFR2 Protein

FGFR2 Antibodies

FGFR2 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA008645GA01HU	FGFR2 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA077444	FGFR2 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA000992	FGFR2 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA449267	FGFR2 Antibody	Human,Mouse	ELISA,IHC
CSB-PA151107	FGFR2 Antibody	Human,Mouse	ELISA,IHC
CSB-PA008645LA01HU	FGFR2 Antibody	Human	ELISA, IHC
CSB-PA008645LB01HU	FGFR2 Antibody, HRP conjugated	Human	ELISA
CSB-PA008645LC01HU	FGFR2 Antibody, FITC conjugated	Human
CSB-RA154582A0HU	FGFR2 Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB
CSB-RA008645MA1HU	FGFR2 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

FGFR2 Proteins

FGFR2 Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP008645CH1 CSB-EP008645CH1 CSB-BP008645CH1 CSB-MP008645CH1 CSB-EP008645CH1-B	Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF008645CH	Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2)	in vitro E.coli expression system

FGFR2 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP008645HU1 CSB-EP008645HU1 CSB-BP008645HU1 CSB-EP008645HU1-B	Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF008645HU	Recombinant Human Fibroblast growth factor receptor 2 (FGFR2)	in vitro E.coli expression system

FGFR2 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP008645MO1 CSB-EP008645MO1 CSB-BP008645MO1 CSB-MP008645MO1 CSB-EP008645MO1-B	Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF008645MO	Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2)	in vitro E.coli expression system

FGFR2 Proteins for Xenopus laevis (African clawed frog)

產品貨號	產品名稱	來源
CSB-YP008645XBE1 CSB-EP008645XBE1 CSB-BP008645XBE1 CSB-MP008645XBE1 CSB-EP008645XBE1-B	Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF008645XBE	Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2)	in vitro E.coli expression system

FGFR2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

產品貨號	產品名稱	來源
CSB-YP008645DIL CSB-EP008645DIL CSB-BP008645DIL CSB-MP008645DIL CSB-EP008645DIL-B	Recombinant Danio rerio Fibroblast growth factor receptor 2 (fgfr2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FGFR2 Proteins for Pleurodeles waltl (Iberian ribbed newt)

產品貨號	產品名稱	來源
CSB-YP008645EWZ CSB-EP008645EWZ CSB-BP008645EWZ CSB-MP008645EWZ CSB-EP008645EWZ-B	Recombinant Pleurodeles waltl Fibroblast growth factor receptor 2 (FGFR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FGFR2 Proteins for Dugesia japonica (Planarian)

產品貨號	產品名稱	來源
CSB-YP008645DMU CSB-EP008645DMU CSB-BP008645DMU CSB-MP008645DMU CSB-EP008645DMU-B	Recombinant Dugesia japonica Fibroblast growth factor receptor 2 (FGFR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FGFR2 Proteins for Notophthalmus viridescens (Eastern newt) (Triturus viridescens)

產品貨號	產品名稱	來源
CSB-YP008645NEO CSB-EP008645NEO CSB-BP008645NEO CSB-MP008645NEO CSB-EP008645NEO-B	Recombinant Notophthalmus viridescens Fibroblast growth factor receptor 2 (FGFR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli