DGAT2
DGAT2，全稱為二酰甘油酰基轉(zhuǎn)移酶2，是一種參與甘油三酯合成的關(guān)鍵酶。它主要存在于脂肪、肝臟和皮膚細(xì)胞中，負(fù)責(zé)催化甘油二酯和?；o酶A生成甘油三酯，是甘油三酯合成過程中的限速酶。DGAT2蛋白的表達(dá)與胰島素信號傳導(dǎo)密切相關(guān)，在高胰島素血癥條件下，DGAT2的表達(dá)會增加，從而促進(jìn)甘油三酯的積累，導(dǎo)致脂肪組織形成和肝臟脂肪變性。
DGAT2蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括非酒精性脂肪性肝?。∟AFLD）、肥胖、高血脂等。NAFLD是一種常見的慢性肝病，其特征是肝臟內(nèi)脂肪過度積累。研究表明，抑制DGAT2的表達(dá)可以有效降低肝臟和血漿中的甘油三酯水平，改善胰島素敏感性和肝臟脂肪變性，從而治療NAFLD。目前，已有多種針對DGAT2的抑制劑被研發(fā)出來，用于治療NAFLD、肥胖等疾病。
熱銷產(chǎn)品
DGAT2 Antibody (CSB-PA850407LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: HepG2 whole cell lysate(30μg), U251 whole cell lysate(30μg), A549 whole cell lysate(30μg), Hela whole cell lysate(30μg), MCF7 whole cell lysate(30μg),K562 whole cell lysate(30μg), Mouse Heart tissue lysate(30μg),Mouse Liver tissue lysate(30μg),Rat Heart tissue lysate(30μg)
All lanes: DGAT2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 40,44 kDa
Observed band size: 44 kDa
Exposure time: 120s
IHC image of CSB-PA850407LA01HU diluted at 1:50 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
DGAT2 Antibodies
DGAT2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA850407LA01HU | DGAT2 Antibody | Human,Rat,Mouse | ELISA, WB,IHC |
DGAT2 Proteins
DGAT2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP850407HU1 CSB-EP850407HU1 CSB-BP850407HU1 CSB-MP850407HU1 CSB-EP850407HU1-B |
Recombinant Human Diacylglycerol O-acyltransferase 2 (DGAT2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF850407HU | Recombinant Human Diacylglycerol O-acyltransferase 2 (DGAT2) | in vitro E.coli expression system |
