CTSZ
CTSZ，全稱為組織蛋白酶Z，是一種溶酶體半胱氨酸蛋白酶，在單核細(xì)胞/巨噬細(xì)胞譜系的細(xì)胞中主要表達(dá)。該蛋白也被稱為組織蛋白酶X或組織蛋白酶P，具有羧基單肽酶和羧基二肽酶活性，并能夠產(chǎn)生激肽增強(qiáng)肽，展現(xiàn)出多功能性。CTSZ在蛋白質(zhì)降解、抗原呈遞、細(xì)胞凋亡和炎癥反應(yīng)等生物學(xué)過程中發(fā)揮重要作用。研究表明，CTSZ的過表達(dá)與腫瘤進(jìn)展（如乳腺癌、結(jié)直腸癌）相關(guān)，可能通過增強(qiáng)細(xì)胞侵襲能力促進(jìn)轉(zhuǎn)移；而降低表達(dá)可能影響免疫細(xì)胞的正常功能，導(dǎo)致炎癥反應(yīng)失調(diào)或感染易感性增加。此外，CTSZ的某些突變可能與溶酶體貯積癥或自身免疫性疾病的發(fā)生有關(guān)。目前，針對CTSZ的藥物研發(fā)主要集中在腫瘤治療領(lǐng)域，例如，有研究探索TRIB3通過抑制CTSZ介導(dǎo)的BCR-ABL降解來調(diào)控BCR-ABL蛋白水平，可能作為急性淋巴細(xì)胞白血病的潛在治療策略。
熱銷產(chǎn)品
CTSZ Antibody (CSB-PA006206LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA006206LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA006206LA01HU at dilution of 1:100
CTSZ Antibodies
CTSZ for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA000038 | Cleaved-CTSZ (L62) Antibody | Human,Monkey | WB, ELISA |
| CSB-PA144023 | CTSZ Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA577887 | CTSZ Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA006206LA01HU | CTSZ Antibody | Human | ELISA, IHC |
| CSB-PA006206LB01HU | CTSZ Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006206LD01HU | CTSZ Antibody, Biotin conjugated | Human | ELISA |
CTSZ Proteins
CTSZ Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006206BO CSB-EP006206BO CSB-BP006206BO CSB-MP006206BO CSB-EP006206BO-B |
Recombinant Bovine Cathepsin Z (CTSZ) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSZ Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP006206RA CSB-MP006206RA CSB-EP006206RA-B |
Recombinant Rat Cathepsin Z (Ctsz) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSZ Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006206HU CSB-EP006206HU CSB-BP006206HU CSB-MP006206HU CSB-EP006206HU-B |
Recombinant Human Cathepsin Z (CTSZ) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSZ Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006206MO CSB-EP006206MO CSB-BP006206MO CSB-MP006206MO CSB-EP006206MO-B |
Recombinant Mouse Cathepsin Z (Ctsz) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
