CSF3R
CSF3R全稱為集落刺激因子3受體，又稱粒細胞集落刺激因子受體（G-CSFR），屬于I型細胞因子受體超家族。CSF3R由胞外配體結合區、跨膜結構域及胞內信號傳導域組成，主要通過與粒細胞集落刺激因子（G-CSF）結合，調控中性粒細胞的增殖、分化及存活。在血液系統疾病中，CSF3R基因突變與先天性中性粒細胞減少癥、慢性中性粒細胞白血病密切相關，特別是截短型突變可導致受體持續激活，引發髓系腫瘤。近年來研究發現，約30%的慢性中性粒細胞白血病患者攜帶該基因突變，成為診斷分型的重要標志。針對CSF3R信號異常，JAK抑制劑魯索替尼已用于攜帶CSF3R-T618I突變患者的臨床治療，而重組G-CSF制劑如培非格司亭則廣泛用于化療后粒細胞缺乏的挽救治療。目前針對該靶點的單克隆抗體藥物及小分子激酶抑制劑已進入臨床試驗階段，為髓系腫瘤精準治療提供新方向。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CSF3R Recombinant Monoclonal Antibody (CSB-RA860321MA1HU)
驗證數據
IHC image of CSB-RA860321MA1HU diluted at 1：100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA860321MA1HU diluted at 1：100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
CSF3R Antibodies
CSF3R for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004693 | CSF3R Antibody | Human | WB, ELISA |
| CSB-PA006057 | CSF3R Antibody | Human | WB, ELISA |
| CSB-PA300322 | CSF3R Antibody | Human | ELISA,IHC |
| CSB-PA094529 | CSF3R Antibody | Human | ELISA,IHC |
| CSB-PA860321LA01HU | CSF3R Antibody | Human | ELISA, IHC, IF |
| CSB-PA860321LB01HU | CSF3R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA860321LC01HU | CSF3R Antibody, FITC conjugated | Human | |
| CSB-PA860321LD01HU | CSF3R Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA860321MA1HU | CSF3R Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CSF3R Proteins
CSF3R Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006050MO CSB-EP006050MO CSB-BP006050MO CSB-MP006050MO CSB-EP006050MO-B |
Recombinant Mouse Granulocyte colony-stimulating factor receptor (Csf3r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF3R Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP860321HU1 | Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | E.coli |
| CSB-YP860321HU CSB-EP860321HU CSB-BP860321HU CSB-MP860321HU CSB-EP860321HU-B |
Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP860321HU2 | Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | E.coli |
| CSB-MP860321HUi10 | Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | Mammalian cell |
