CDH17
CDH17，即鈣粘蛋白17，別名LI-cadherin。CDH17是一種7D-cadherin家族的成員，其胞外域由EC1-EC7七個(gè)重復(fù)序列構(gòu)成，胞內(nèi)域含18-20個(gè)氨基酸。CDH17的功能是作為多肽轉(zhuǎn)運(yùn)器和細(xì)胞粘附分子來維持上皮組織的完整性。CDH17的粘附機(jī)制與典型cadherin不同，它不需要與α和β-catenins復(fù)合，能在不與其他細(xì)胞質(zhì)成分相互作用的情況下保持粘合功能。CDH17在正常人類細(xì)胞中僅在小腸和結(jié)腸中高表達(dá)，而在肝臟、心臟和腎臟等其他組織中不表達(dá)或低表達(dá)。然而，在腫瘤組織中，CDH17在胃、胰腺、肝、食道、膽管癌和結(jié)直腸癌中過表達(dá)，其表達(dá)異常與腫瘤的形成和轉(zhuǎn)移密切相關(guān)。CDH17是消化系統(tǒng)惡性腫瘤的潛在診斷標(biāo)志物和治療靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Cadherin-17 (CDH17), partial (Active) (CSB-MP613267HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 at 2μg/mL can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA1HU), the EC50 is 3.095 to 4.451 ng/mL.
Recombinant Human Cadherin-1(CDH1),partial (Active) (CSB-MP005034HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDH1 at 2μg/mL can bind Anti-CDH1 recombinant antibody(CSB-RA005034MA2HU)，the EC50 is 5.151-6.358 ng/mL.
Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) (CSB-MP4664MOV)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDH17 at 2 μg/ml can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA3HU). The EC50 is 2.182-2.529 ng/mL.
Recombinant Rat Cadherin-17 (Cdh17), partial (Active) (CSB-MP005042RA)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Rat CDH17 at 2 μg/ml can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA3HU). The EC50 is 13.06-14.24 ng/mL.
CDH17 Recombinant Monoclonal Antibody (CSB-RA613267MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human CDH17 with Anti-CDH17 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 (CSB-MP613267HU) at 2 μg/mL can bind Anti-CDH17 recombinant antibody, the EC50 is 3.095-4.451 ng/mL.
Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
CDH17 Antibodies
CDH17 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA613267ESR1HU | CDH17 Antibody | Human | ELISA, IHC |
| CSB-PA212083 | CDH17 Antibody | Human | ELISA,WB,IF |
| CSB-PA006407 | CDH17 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA017530LA01HU | PCDH17 Antibody | Human | ELISA, IF |
| CSB-PA017530LD01HU | PCDH17 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA017530LC01HU | PCDH17 Antibody, FITC conjugated | Human | |
| CSB-PA017530LB01HU | PCDH17 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA613267MA1HU | CDH17 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CDH17 Proteins
CDH17 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005042RA CSB-EP005042RA CSB-BP005042RA CSB-EP005042RA-B |
Recombinant Rat Cadherin-17 (Cdh17), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CDH17 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017530HU CSB-EP017530HU CSB-BP017530HU CSB-MP017530HU CSB-EP017530HU-B |
Recombinant Human Protocadherin-17 (PCDH17), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP613267HU CSB-BP613267HU CSB-EP613267HU-B |
Recombinant Human Cadherin-17 (CDH17), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP613267HU | Recombinant Human Cadherin-17 (CDH17), partial (Active) | Mammalian cell |
CDH17 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP882608MO CSB-MP882608MO CSB-EP882608MO-B |
Recombinant Mouse Cadherin-17 (Cdh17), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP882608MO | Recombinant Mouse Cadherin-17 (Cdh17), partial | E.coli |
| CSB-YP882608MO | Recombinant Mouse Cadherin-17 (Cdh17), partial | Yeast |
| CSB-MP882608MO1 | Recombinant Mouse Cadherin-17 (Cdh17), partial | Mammalian cell |
