CD2AP
CD2AP，全稱CD2-associated protein，是一種廣泛存在于細胞中的蛋白質(zhì)。它最初在外周免疫細胞中與CD2蛋白相互作用而被發(fā)現(xiàn)，后來研究發(fā)現(xiàn)它與多種細胞過程密切相關，包括細胞骨架重排、細胞信號傳導和細胞內(nèi)吞作用等。CD2AP通過與多種蛋白相互作用，在細胞內(nèi)形成一個復雜的蛋白質(zhì)網(wǎng)絡，參與調(diào)節(jié)細胞的形態(tài)和功能。
CD2AP與多種疾病的發(fā)生發(fā)展密切相關，包括阿爾茨海默病、腎病綜合征和某些類型的癌癥等。在阿爾茨海默病中，CD2AP參與淀粉樣蛋白的代謝和tau蛋白的病理過程，其表達異常與疾病的發(fā)生發(fā)展密切相關。在腎病綜合征中，CD2AP表達異常導致腎小球濾過膜結構破壞，引發(fā)腎臟疾病。此外，CD2AP還與某些類型的癌癥的發(fā)生發(fā)展密切相關，例如結腸癌、乳腺癌和肺癌等。
針對CD2AP相關疾病的治療藥物研發(fā)尚處于起步階段。由于CD2AP在多種生理過程中發(fā)揮重要作用，因此針對其研發(fā)的藥物需要謹慎選擇作用靶點和作用機制，以避免產(chǎn)生不良反應。未來，隨著對CD2AP作用機制的深入研究，相信會有更多針對CD2AP相關疾病的藥物被研發(fā)出來，為患者帶來新的治療選擇。
熱銷產(chǎn)品
CD2AP Antibody (CSB-PA004914LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: CD2AP antibody at 11μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72 kDa
Observed band size: 72 kDa
IHC image of CSB-PA004914LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA004914LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human CD2-associated protein(CD2AP) ELISA kit (CSB-EL004914HU)
驗證數(shù)據(jù)
貨號：CSB-EL004914HU
規(guī)格：96T/48T
靈敏度：4.7 pg/mL
檢測范圍：18.75 pg/mL-1200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CD2AP Antibodies
CD2AP for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004914GA01HU | CD2AP Antibody | Human,Mouse | ELISA,WB |
| CSB-PA126362 | CD2AP Antibody | Human | ELISA,WB,IHC |
| CSB-PA790945 | CD2AP Antibody | Human | ELISA,WB,IHC |
| CSB-PA004914LA01HU | CD2AP Antibody | Human, Rat | ELISA, WB, IHC, IF |
CD2AP Proteins
CD2AP Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004914HU CSB-EP004914HU CSB-BP004914HU CSB-MP004914HU CSB-EP004914HU-B |
Recombinant Human CD2-associated protein (CD2AP) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD2AP ELISA Kit
CD2AP ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL004914HU | Human CD2-associated protein(CD2AP) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 4.7 pg/mL |
