CASP4
CASP4，全稱胱天冬酶4，是一種參與細胞凋亡和炎癥反應的蛋白酶。該蛋白常見別名包括ICE(rel)II、ICEREL-II、ICH-2、Mih1/TX、TX、Mih1等。CASP4主要通過識別革蘭氏陰性菌脂多糖（LPS）激活非經典炎癥通路，進而切割Gasdermin D（GSDMD）并介導細胞焦亡和炎癥因子釋放。研究發(fā)現(xiàn)，CASP4能夠切割AKT1的D108位點，移除其PH自抑制結構域，釋放激酶活性核心，提示細胞焦亡通路可能通過AKT1調控網絡與細胞存活、代謝等進程產生交叉對話。此外，CASP4對同家族蛋白酶Caspase-5/12前體的激活作用，揭示了炎癥性caspase間存在級聯(lián)放大機制。CASP4與多種疾病相關，如感染性疾病和炎癥相關疾病。目前，針對CASP4的藥物研發(fā)正在積極進行中，例如抗炎藥吲哚布洛芬是CASP4酶活性的抑制劑。此外，CASP4抗體等診斷試劑的研發(fā)也為相關疾病的研究提供了有力工具。
熱銷產品
Recombinant Human Caspase-4 (CASP4) (CSB-EP004549HU(A4))
驗證數(shù)據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CASP4 Antibodies
CASP4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004549GA01HU | CASP4 Antibody | Human | ELISA,WB,IHC |
| CSB-PA000023 | Cleaved-CASP4 (Q81) Antibody | Human | WB, IHC, ELISA |
| CSB-PA060273 | CASP4 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA004549LA01HU | CASP4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CASP4 Proteins
CASP4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004549MO CSB-EP004549MO CSB-BP004549MO CSB-MP004549MO CSB-EP004549MO-B |
Recombinant Mouse Caspase-4 (Casp4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004549HU CSB-EP004549HU CSB-BP004549HU CSB-MP004549HU CSB-EP004549HU-B |
Recombinant Human Caspase-4 (CASP4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004549HU(A4) | Recombinant Human Caspase-4 (CASP4) | E.coli |
CASP4 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP691616BO CSB-EP691616BO CSB-BP691616BO CSB-MP691616BO CSB-EP691616BO-B |
Recombinant Bovine Caspase-4 (CASP4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP4 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP866914DOA1 CSB-EP866914DOA1 CSB-BP866914DOA1 CSB-MP866914DOA1 CSB-EP866914DOA1-B |
Recombinant Arabidopsis thaliana Casparian strip membrane protein 4 (CASP4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF866914DOA | Recombinant Arabidopsis thaliana Casparian strip membrane protein 4 (CASP4) | in vitro E.coli expression system |
