BTLA
BTLA，即B和T淋巴細胞弱化因子，別名BTNL9、BTLA。它是一種主要在T細胞、B細胞和NK細胞上表達的免疫檢查點分子，由人體細胞自身的基因編碼。BTLA的作用機制涉及與其特異性配體HVEM（皰疹病毒入侵介質）結合，這種結合能夠抑制T細胞和B細胞的活化、增殖以及細胞因子的生成。BTLA與HVEM的結合通過激活免疫受體酪氨酸的抑制基序（ITIM）和免疫球蛋白酪氨酸開關基序（ITSM），導致SHP-1和SHP-2的磷酸化和募集，從而抑制T細胞的增殖和IL-2的產生，產生免疫抑制效應 。BTLA參與了多種生理和病理過程的調節，包括腫瘤、炎癥性疾病、自身免疫性疾病等。在腫瘤微環境中，BTLA的激活是PD-1抗體的潛在耐藥機制之一，BTLA的表達與腫瘤的進展密切相關。在炎癥性疾病中，BTLA對T細胞介導的炎癥具有負調節作用。此外，在自身免疫性疾病中，BTLA的表達水平與疾病的活動性相關。因此，BTLA是免疫學研究和相關疾病治療中的一個潛在靶點 。
熱銷產品
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) (CSB-MP773799HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized BTLA at 5 μg/ml can bind biotinylated human TNFRSF14 (CSB-MP842173HU-A), the EC50 is 137.8-233.4 ng/ml.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human BTLA at 2μg/ml can bind Anti-BTLA recombinant antibody(CSB-RA773799MAIHU), the EC50 is 1.763-3.542 ng/mL.
BTLA Recombinant Monoclonal Antibody (CSB-RA773799MA1HU)
驗證數據
The Binding Activity of Human BTLA with Anti-BTLA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human BTLA(CSB-MP773799HU1)at 2 μg/mL can bind Anti-BTLA recombinant antibody , the EC50 is 11.56-13.00 ng/mL.
Untransfected Jurkat cells surface (green line) and transfected Human BTLA Jurkat stable cells surface (red line) were stained with anti-BTLA antibody (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Untransfected CHO-K1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
BTLA Antibodies
BTLA for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA921165 | BTLA Antibody | Human | ELISA,WB |
| CSB-PA007471 | BTLA Antibody | Human | WB, ELISA |
| CSB-PA100659 | BTLA Antibody | Human | ELISA,IHC |
| CSB-PA921825 | BTLA Antibody | Human | ELISA,IHC |
| CSB-PA446647 | BTLA Antibody | Human | IHC,ELISA |
| CSB-RA773799MA1HU | BTLA Recombinant Monoclonal Antibody | Human | ELISA, FC |
BTLA Proteins
BTLA Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP742519MO CSB-EP742519MO CSB-BP742519MO CSB-MP742519MO CSB-EP742519MO-B |
Recombinant Mouse B- and T-lymphocyte attenuator (Btla), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BTLA Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP744141RA CSB-EP744141RA CSB-BP744141RA CSB-MP744141RA CSB-EP744141RA-B |
Recombinant Rat B- and T-lymphocyte attenuator (Btla), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BTLA Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP773799HU CSB-EP773799HU CSB-BP773799HU CSB-EP773799HU-B |
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP773799HU | Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) | Mammalian cell |
| CSB-MP773799HU-B | Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial,Biotinylated | Mammalian cell |
| CSB-MP773799HU1 | Recombinant Human B- and T-lymphocyte attenuator(BTLA), partial (Active) | Mammalian cell |
BTLA ELISA Kit
BTLA ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL002868HU | Human B- and T-lymphocyte attenuator(BTLA) ELISA kit | serum, plasma, tissue homogenates | 0.11 ng/mL |
BTLA ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL002868MO | Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
