BTK
BTK，即布魯頓酪氨酸激酶，別名AGMX1 ATK BPK。它是一種非受體酪氨酸激酶，屬于Tec激酶家族成員，在所有造血細胞中廣泛存在，除了T細胞和漿細胞。BTK的作用機制主要是通過參與B細胞受體（BCR）信號通路，傳遞BCR接受到的信號并調控B細胞的增殖和存活。BTK包含5個結構域：PH結構域、TH結構域、SH3結構域、SH2結構域和SH1/TK催化結構域，這些結構域可以識別并結合多種信號分子 。BTK在生物學上的意義非常廣泛，它不僅參與了B細胞的成熟、存活、分化、凋亡、遷移等過程，還涉及了多種疾病的發生發展，尤其是在B細胞淋巴瘤中，BTK是BCR信號通路中的關鍵激酶。BTK抑制劑可以與BTK活性中心的半胱氨酸殘基共價結合，從而抑制其活性，進而抑制BCR信號通路的激活，有效阻止腫瘤從B細胞遷移至適宜腫瘤生長的淋巴組織，減少B細胞惡性增殖并誘導細胞的凋亡，從而發揮治療作用 。
熱銷產品
Recombinant Human Tyrosine-protein kinase BTK (BTK) (CSB-BP002867HU(A4))
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BTK Recombinant Monoclonal Antibody (CSB-RA553167A0HU)
驗證數據
IHC image of CSB-RA553167A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
BTK Antibodies
BTK for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA002867GA01HU | BTK Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA142166 | Phospho-BTK (Tyr223) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000638 | Phospho-BTK (Y223) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA000639 | Phospho-BTK (Y551) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA001066 | BTK Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA005537 | BTK Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA002867LA01HU | BTK Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA002867LB01HU | BTK Antibody, HRP conjugated | Human | ELISA |
| CSB-PA002867LC01HU | BTK Antibody, FITC conjugated | Human | |
| CSB-PA002867LD01HU | BTK Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA553167A0HU | BTK Recombinant Monoclonal Antibody | Human | ELISA, IHC |
BTK Proteins
BTK Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP002867MO CSB-BP002867MO CSB-MP002867MO CSB-EP002867MO-B |
Recombinant Mouse Tyrosine-protein kinase BTK (Btk) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BTK Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP814261CH CSB-EP814261CH CSB-BP814261CH CSB-MP814261CH CSB-EP814261CH-B |
Recombinant Chicken Tyrosine-protein kinase BTK (BTK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BTK Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP002867HU | Recombinant Human Tyrosine-protein kinase BTK (BTK) | Yeast |
| CSB-EP002867HU CSB-MP002867HU CSB-EP002867HU-B |
Recombinant Human Tyrosine-protein kinase BTK (BTK) | E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP002867HU(A4) | Recombinant Human Tyrosine-protein kinase BTK (BTK) | Baculovirus |
| CSB-EP002867HU1 | Recombinant Human Tyrosine-protein kinase BTK (BTK), partial | E.coli |
