AMFR
E3 ubiquitin-protein ligase AMFR is a protein in humans that is encoded by AMFR gene. E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
AMFR Antibodies
AMFR for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA001665GA01HU | AMFR Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA333164LA01HU | AMFR Antibody | Human | ELISA, WB, IHC |
AMFR Proteins
AMFR Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP886413MO1 CSB-EP886413MO1 CSB-BP886413MO1 CSB-MP886413MO1 CSB-EP886413MO1-B |
Recombinant Mouse E3 ubiquitin-protein ligase AMFR (Amfr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF886413MO | Recombinant Mouse E3 ubiquitin-protein ligase AMFR (Amfr) | in vitro E.coli expression system |
AMFR Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP892337HU1 CSB-BP892337HU1 |
Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR), partial | Yeast Baculovirus |
| CSB-CF892337HU | Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR) | in vitro E.coli expression system |
| CSB-MP892337HU1 | Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR), partial | Mammalian cell |
| CSB-EP892337HU1-B | Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR), partial,Biotinylated | E.coli |
| CSB-EP892337HU1 | Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR), partial | E.coli |
| CSB-MP892337HU | Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR)-VLPs | Mammalian cell |
