AIFM1
Apoptosis-inducing factor 1, mitochondrial is a protein in humans that is encoded by AIFM1 gene. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
AIFM1 Antibodies
AIFM1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA001492GA01HU | AIFM1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001492HA01HU | AIFM1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA000836 | AIFM1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA068462 | AIFM1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA480938 | AIFM1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA296617A0HU | AIFM1 Recombinant Monoclonal Antibody | Human, Rat | ELISA, WB, IHC |
| CSB-RA001492MA1HU | AIFM1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, FC |
AIFM1 Proteins
AIFM1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001492HU CSB-BP001492HU CSB-MP001492HU CSB-EP001492HU-B |
Recombinant Human Apoptosis-inducing factor 1, mitochondrial (AIFM1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001492HU | Recombinant Human Apoptosis-inducing factor 1, mitochondrial (AIFM1), partial | E.coli |
AIFM1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP872890RA CSB-EP872890RA CSB-BP872890RA CSB-MP872890RA CSB-EP872890RA-B |
Recombinant Rat Apoptosis-inducing factor 1, mitochondrial (Aifm1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AIFM1 ELISA Kit
AIFM1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09006h | Human apoptosis inducing factor,AIF ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |
