ADORA2A
腺苷A2A受體（ADORA2A）是嘌呤能受體家族成員，又稱A2AR，廣泛分布于中樞神經(jīng)系統(tǒng)、免疫細(xì)胞及心血管組織。ADORA2A通過與內(nèi)源性腺苷結(jié)合，調(diào)控細(xì)胞內(nèi)cAMP水平，影響多巴胺能神經(jīng)傳遞，在運(yùn)動協(xié)調(diào)、睡眠調(diào)節(jié)和免疫抑制中發(fā)揮關(guān)鍵作用。研究顯示其活性異常與帕金森病的運(yùn)動功能障礙密切相關(guān)，阻斷該受體可增強(qiáng)左旋多巴療效。在腫瘤微環(huán)境中，A2AR激活會抑制T細(xì)胞抗腫瘤活性，這一發(fā)現(xiàn)推動了其與PD-1抑制劑聯(lián)用的臨床試驗(yàn)。
目前已有選擇性A2AR拮抗劑伊曲茶堿（istradefylline）在日本獲批用于帕金森病治療，可改善劑末現(xiàn)象。針對癌癥免疫治療領(lǐng)域，多個(gè)小分子抑制劑如AZD4635已進(jìn)入II期試驗(yàn)，與免疫檢查點(diǎn)藥物聯(lián)用顯示出協(xié)同效應(yīng)。在神經(jīng)精神疾病方面，A2AR調(diào)控異常還與成癮行為、雙相情感障礙相關(guān)，相關(guān)藥物研發(fā)正探索其對認(rèn)知功能的調(diào)節(jié)作用。ADORA2A同時(shí)成為咖啡因的作用靶點(diǎn)之一，解釋了咖啡因提神效果的部分分子基礎(chǔ)。
熱銷產(chǎn)品
ADORA2A Antibody (CSB-PA001376LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001376LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA001376LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA001376LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ADORA2A Antibodies
ADORA2A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007176 | ADORA2A Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA007183 | ADORA2A Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA001376LA01HU | ADORA2A Antibody | Human | ELISA, IHC, IF |
| CSB-PA001376LC01HU | ADORA2A Antibody, FITC conjugated | Human | |
| CSB-PA001376LD01HU | ADORA2A Antibody, Biotin conjugated | Human | ELISA |
ADORA2A Proteins
ADORA2A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001376DO1 CSB-EP001376DO1 CSB-BP001376DO1 CSB-MP001376DO1 CSB-EP001376DO1-B |
Recombinant Dog Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001376DO | Recombinant Dog Adenosine receptor A2a (ADORA2A) | in vitro E.coli expression system |
ADORA2A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001376HU CSB-EP001376HU CSB-BP001376HU CSB-MP001376HU CSB-EP001376HU-B |
Recombinant Human Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADORA2A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001376RA1 CSB-EP001376RA1 CSB-BP001376RA1 CSB-MP001376RA1 CSB-EP001376RA1-B |
Recombinant Rat Adenosine receptor A2a (Adora2a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001376RA | Recombinant Rat Adenosine receptor A2a (Adora2a) | in vitro E.coli expression system |
ADORA2A Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001376GU1 CSB-EP001376GU1 CSB-BP001376GU1 CSB-MP001376GU1 CSB-EP001376GU1-B |
Recombinant Guinea pig Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001376GU | Recombinant Guinea pig Adenosine receptor A2a (ADORA2A) | in vitro E.coli expression system |
ADORA2A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP720158MO1 CSB-BP720158MO1 CSB-MP720158MO1 CSB-EP720158MO1-B |
Recombinant Mouse Adenosine receptor A2a (Adora2a), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF720158MO | Recombinant Mouse Adenosine receptor A2a (Adora2a) | in vitro E.coli expression system |
ADORA2A Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP744229HO1 CSB-EP744229HO1 CSB-BP744229HO1 CSB-MP744229HO1 CSB-EP744229HO1-B |
Recombinant Horse Adenosine receptor A2a (ADORA2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF744229HO | Recombinant Horse Adenosine receptor A2a (ADORA2A) | in vitro E.coli expression system |
