NRG1
NRG1，即神經(jīng)調(diào)節(jié)蛋白1，別名HRG、NDF、GGF。這是一種由人類(lèi)NRG1基因編碼的蛋白質(zhì)，屬于表皮生長(zhǎng)因子（EGF）家族。NRG1主要是通過(guò)其異構(gòu)體與ErbB家族受體結(jié)合，激活多重下游信號(hào)通路，如PI3K/Akt、MAPK/ERK等，從而促進(jìn)細(xì)胞增殖、分化，抑制細(xì)胞凋亡，調(diào)節(jié)能量利用，并增強(qiáng)血管生成。NRG1的表達(dá)和功能異常與多種疾病的發(fā)生發(fā)展相關(guān)，包括腫瘤、心血管疾病、神經(jīng)精神疾病等。在腫瘤領(lǐng)域，NRG1基因融合是一種新興的、潛在的致癌驅(qū)動(dòng)因素，與多種腫瘤的發(fā)生發(fā)展相關(guān)，如非小細(xì)胞肺癌、腎癌、甲狀腺癌等。在心血管疾病中，NRG1/ErbB信號(hào)通路在心臟的發(fā)育、心肌增殖分化及心臟傳導(dǎo)系統(tǒng)的形成過(guò)程中起到了重要作用，并在心血管急慢性疾病中對(duì)心肌細(xì)胞具有保護(hù)功能。因此，NRG1被認(rèn)為是這些疾病潛在的治療靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized NRG1 at 2 μg/ml can bind human ERBB3(CSB-MP007765HU), the EC50 is 18.24-23.66 ng/ml.
-AC2.jpg)
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of MCF-7 cells is 2.626-7.598 ng/mL.
-HPLC.jpg)
The purity of NRG1 was greater than 95% as determined by SEC-HPLC
NRG1 Antibodies
NRG1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA016077GA01HU | NRG1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA005465 | NRG1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA970558 | NRG1 Antibody | Human | ELISA,WB |
| CSB-PA940332 | NRG1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA965247 | NRG1 Antibody | Human | ELISA,WB |
| CSB-PA09589A0Rb | NRG1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA09589B0Rb | NRG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA09589C0Rb | NRG1 Antibody, FITC conjugated | Human | |
| CSB-PA09589D0Rb | NRG1 Antibody, Biotin conjugated | Human | ELISA |
NRG1 Proteins
NRG1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP016077RA1 CSB-EP016077RA1 CSB-BP016077RA1 CSB-MP016077RA1 CSB-EP016077RA1-B |
Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016077RA | Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1) | in vitro E.coli expression system |
NRG1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP526051XBE CSB-EP526051XBE CSB-BP526051XBE CSB-MP526051XBE CSB-EP526051XBE-B |
Recombinant Xenopus laevis Pro-neuregulin-1, membrane-bound isoform (nrg1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NRG1 Proteins for Homo sapiens (Human)
