NFE2L2
NFE2L2，即核因子（紅細胞衍生2）相關(guān)因子2，別名NRF2、NFE2L2。它是一種轉(zhuǎn)錄因子，由人體細胞自身的基因編碼，在細胞防御氧化應激和清除有害物質(zhì)中發(fā)揮關(guān)鍵作用。NFE2L2的作用機制涉及多個層面，包括翻譯后修飾、蛋白相互作用和表觀遺傳調(diào)控等。在正常生理條件下，NFE2L2與KEAP1結(jié)合并通過泛素-蛋白酶體途徑促進其降解，維持NFE2L2表達在較低水平。當細胞遭遇氧化應激或親電試劑時，NFE2L2會從細胞質(zhì)轉(zhuǎn)移到細胞核，與抗氧化反應元件(ARE)結(jié)合，激活抗氧化相關(guān)基因的轉(zhuǎn)錄。NFE2L2在生物學上的意義非常廣泛，它參與調(diào)控黃曲霉毒素分解代謝過程、大分子代謝過程的正向調(diào)控以及細胞遷移的調(diào)節(jié)。NFE2L2的功能異常與多種疾病相關(guān)，包括糖尿病視網(wǎng)膜病變、肝硬化、大腦中動脈梗塞、非酒精性脂肪肝病等。此外，NFE2L2的人類直系同源基因與阿爾茨海默病、白內(nèi)障、肝細胞癌、黃斑變性、肺結(jié)核等疾病有關(guān)。在癌癥中，NFE2L2-KEAP1信號通路經(jīng)常被劫持，尤其是在非小細胞肺癌中，NFE2L2的激活可導致癌細胞逃脫各種抗腫瘤治療，促進疾病進展和轉(zhuǎn)移。因此，NFE2L2是細胞氧化應激反應和疾病治療中的一個重要靶點。
熱銷產(chǎn)品
Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial (CSB-EP614961HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NFE2L2 Recombinant Monoclonal Antibody (CSB-RA225569A0HU)
驗證數(shù)據(jù)
Immunofluorescence staining of Hela Cells with CSB-RA225569A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
NFE2L2 Antibodies
NFE2L2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA009136GA01HU | NFE2L2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA828758 | NFE2L2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000152 | Acetyl-NFE2L2 (K599) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA003481 | NFE2L2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA005517 | NFE2L2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA080280 | NFE2L2 Antibody | Human,Mouse,Rat | WB, IHC |
| CSB-PA777170 | NFE2L2 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-RA614961A40phHU | Phospho-NFE2L2 (S40) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA614961LA01HU | NFE2L2 Antibody | Human | ELISA, IF |
| CSB-PA614961LB01HU | NFE2L2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA614961LC01HU | NFE2L2 Antibody, FITC conjugated | Human | |
| CSB-PA614961LD01HU | NFE2L2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA225569A0HU | NFE2L2 Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-MA614961A0m | NFE2L2 Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC, IF, FC |
NFE2L2 Proteins
NFE2L2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015752RA CSB-EP015752RA CSB-BP015752RA CSB-MP015752RA CSB-EP015752RA-B |
Recombinant Rat Nuclear factor erythroid 2-related factor 2 (Nfe2l2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFE2L2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP614961HU CSB-BP614961HU CSB-MP614961HU CSB-EP614961HU-B |
Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP614961HU | Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2) | E.coli |
| CSB-EP614961HU1 | Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial | E.coli |
NFE2L2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP708916BO CSB-EP708916BO CSB-BP708916BO CSB-MP708916BO CSB-EP708916BO-B |
Recombinant Bovine Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFE2L2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP726674MO CSB-BP726674MO CSB-MP726674MO CSB-EP726674MO-B |
Recombinant Mouse Nuclear factor erythroid 2-related factor 2 (Nfe2l2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFE2L2 ELISA Kit
NFE2L2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL015752HU | Human Nuclear factor erythroid 2-related factor 2(NFE2L2) ELISA kit | serum, plasma, urine, tissue homogenates, cell lysates | 7.8 pg/mL |
NFE2L2 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16188m | Mouse Nuclear factor erythroid 2-related factor 2 (Nrf2) ELISA Kit | serum, plasma, cell culture supernates | 0.078 ng/mL |
