IL2RB
白細胞介素-2受體β鏈（IL-2RB）又稱CD122，是免疫調(diào)節(jié)中的關鍵膜蛋白。該分子通過與γ鏈共同構成功能性受體復合物，在激活T細胞和自然殺傷細胞中發(fā)揮核心作用。IL2RB功能異常與多種免疫疾病密切相關，例如系統(tǒng)性紅斑狼瘡患者常出現(xiàn)該受體信號傳導紊亂，而霍奇金淋巴瘤等血液腫瘤中則存在受體過度激活現(xiàn)象。臨床上已有針對IL-2受體的人源化單抗藥物，如巴利昔單抗被用于預防腎移植排斥反應。近年研究聚焦于開發(fā)選擇性調(diào)節(jié)劑，利用該受體在調(diào)節(jié)性T細胞與效應T細胞中的差異化表達特征，旨在實現(xiàn)更精準的免疫平衡控制。在腫瘤免疫治療領域，部分處于Ⅱ期臨床試驗的雙特異性抗體通過靶向CD122增強抗腫瘤免疫應答，為實體瘤治療提供了新思路。
熱銷產(chǎn)品
驗證數(shù)據(jù)
Western blot analysis on HeLa cell lysate using IL-2Rbeta/CD122 antibody,The lane on the left is treated with the antigen-specific peptide.
IL2RB Antibodies
IL2RB for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011650GA01HU | IL2RB Antibody | Human | ELISA,WB |
| CSB-PA081831 | IL2RB Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA163341 | Phospho-IL2RB (Tyr364) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA832482 | IL2RB (Ab-364) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA009546 | Phospho-IL2RB (Y364) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA009547 | Phospho-IL2RB (Y364) Antibody | Human,Mouse,Rat,Monkey | WB, ELISA |
| CSB-PA009548 | IL2RB Antibody | Human | WB, ELISA |
| CSB-PA009549 | IL2RB Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA009550 | IL2RB Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA061951 | IL2RB Antibody | Human | ELISA,WB,IHC |
| CSB-PA114100 | IL2RB Antibody | Human | ELISA,WB,IHC |
IL2RB for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011650LB01MO | Il2rb Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA011650LA01MO | Il2rb Antibody | Mouse | ELISA |
| CSB-PA011650LC01MO | Il2rb Antibody, FITC conjugated | Mouse |
IL2RB Proteins
IL2RB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011650HU1 CSB-EP011650HU1 CSB-BP011650HU1 CSB-MP011650HU1 CSB-EP011650HU1-B |
Recombinant Human Interleukin-2 receptor subunit beta (IL2RB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011650HU | Recombinant Human Interleukin-2 receptor subunit beta (IL2RB) | in vitro E.coli expression system |
IL2RB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011650MO | Recombinant Mouse Interleukin-2 receptor subunit beta (Il2rb), partial | Yeast |
| CSB-EP011650MO1 | Recombinant Mouse Interleukin-2 receptor subunit beta (Il2rb), partial | E.coli |
IL2RB Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011650RA1 CSB-EP011650RA1 CSB-BP011650RA1 CSB-EP011650RA1-B |
Recombinant Rat Interleukin-2 receptor subunit beta (Il2rb), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF011650RA | Recombinant Rat Interleukin-2 receptor subunit beta (Il2rb) | in vitro E.coli expression system |
IL2RB Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP654343EQV CSB-EP654343EQV CSB-BP654343EQV CSB-MP654343EQV CSB-EP654343EQV-B |
Recombinant Pan troglodytes Interleukin-2 receptor subunit beta (IL2RB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP657828MOV CSB-BP657828MOV CSB-EP657828MOV-B |
Recombinant Macaca fascicularis Interleukin-2 receptor subunit beta (IL2RB), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP657828MOV | Recombinant Macaca fascicularis Interleukin-2 receptor subunit beta (IL2RB), partial | E.coli |
