Recombinant Rat Syndecan-4 (Sdc4)

in vitro E.coli expression system

中文名稱：

大鼠Sdc4重組蛋白
貨號：

CSB-CF020891RA
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Sdc4
Uniprot No.：

P34901
別名：

Sdc4; Synd4; Syndecan-4; SYND4; Ryudocan core protein
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

24-202
氨基酸序列

ESIRETEVIDPQDLLEGRYFSGALPDDEDAGGLEQDSDFELSGSGDLDDTEEPRTFPEVISPLVPLDNHIPENAQPGIRVPSEPKELEENEVIPKRVPSDVGDDDVSNKVSMSSTSQGSNIFERTEVLAALIVGGVVGILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
基因功能參考文獻：
1. syntenin-1 negatively regulates syndecan-4 function via oligomerization and/or syndecan-4 interaction, impacting cytoskeletal organization and cell migration. PMID: 27830760
2. syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc PMID: 26272378
3. This study provided evidence for the differential regulation by MAPK and NF-kappaB pathways in the over-expression of syndecan-4 promoted by TNF-alpha in NP cells PMID: 25491150
4. Locally generated Sdc4 may play a role in regulating TRPC6 channels, and may contribute to glomerular pathology. PMID: 26193076
5. Syndecan-2 and -4 form heterdimer and this interaction regulates syndecan-mediated cellular functions. PMID: 25979339
6. SDC4 participates in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression. PMID: 25174688
7. in healthy discs, SDC4, through its heparan sulfate side chains, contributes to maintenance of the hypoxic tissue niche by controlling baseline expression of Sox9. PMID: 24558194
8. data suggest that the transmembrane domain plays a major role in regulating syndecan-4 functions, and show that a domain hierarchy exists in the regulation of syndecan-4 PMID: 22504297
9. Expression of the proteoglycan syndecan-4 and the mechanism by which it mediates stress fiber formation in folliculostellate cells in the rat anterior pituitary gland. PMID: 22645300
10. results support liposomal delivery of syndecan-4 as an effective means to improving the potential of using growth factors to achieve therapeutic neovascularization of ischemic tissue PMID: 22307630
11. Pravastatin can inhibit the proliferation and syndean-4 protein expression in rat vascular smooth muscle cells induced by TNF-alpha in vitro. PMID: 20501378
12. Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles. PMID: 21518435
13. Clustering induces redistribution of syndecan-4 core protein into raft membrane domains PMID: 11889131
14. Syndecan-4 mRNA expression is not regulated by the FSH/cAMP/calcium pathway. PMID: 12135485
15. Syn-4 is localized to a cytoskeletal adhesion complex unique to striated muscle, the costamere. Soon after redifferentiation of myofibrils in cultured neonatal cardiomyocytes, syn-4 is present only in costameres, not in focal adhesions. PMID: 12209563
16. SDC4 regulates inositol phospholipid binding and signaling PMID: 12377772
17. the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner PMID: 12493766
18. Syndecan-4 can promote cell spreading in a beta(1) integrin-dependent fashion through PKCalpha and RhoA PMID: 12509413
19. syndecan-4 binds PKC alpha and localizes it to focal adhesions, whose assembly may be regulated by the kinase PMID: 12571249
20. FGF2 endocytosis requires syndecan-4 clustering-dependent activation of Rac1 and the intact CDC42-dependent macropinocytic pathway PMID: 15226395
21. phosphorylation (Ser183) of syndecan-4 can play a critical role as a molecular switch to regulate its functions through conformational change PMID: 16310216
22. Syndecan-4 signals to RhoA in a PKCalpha-dependent manner. PMID: 16787950
23. mitogen-triggered syndecan-4 expression is an intrinsic part of the pathways subtending osteoblast proliferation and mineralization PMID: 16924669
24. Syndecan-4 cytoplasmic domain forms a dimer stabilized by ionic interactions between peptides at physiological pH, a tendency which may be important for its role in regulating protein kinase C activity during focal adhesion formation. PMID: 11456484
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亞細胞定位：

Membrane; Single-pass type I membrane protein. Secreted.
蛋白家族：

Syndecan proteoglycan family
數(shù)據(jù)庫鏈接：

KEGG: rno:24771

STRING: 10116.ENSRNOP00000019386

UniGene: Rn.2029